Body Composition: Key Words
Undernutrition is insufficiently detected in in- and outpatients, and this is likely to worsen during the next decades. The increased prevalence of obesity together with chronic illnesses associated with fat-free mass (FFM) loss will result in an increased prevalence of sarcopenic obesity. In patients with sarcopenic obesity, weight loss and the body mass index lack accuracy to detect FFM loss. FFM loss is related to increasing mortality, worse clinical outcomes, and impaired quality of life. In sarcopenic obesity and chronic diseases, body composition measurement with dual-energy X-ray absorptiometry, bioelectrical impedance analysis, or computerized tomography quantifies the loss of FFM. It allows tailored nutritional support and disease-specific therapy and reduces the risk of drug toxicity. Body composition evaluation should be integrated into routine clinical practice for the initial assessment and sequential follow-up of nutritional status. It could allow objective, systematic, and early screening of undernutrition and promote the rational and early initiation of optimal nutritional support, thereby contributing to reducing malnutrition-induced morbidity, mortality, worsening of the quality of life, and global health care costs.
Sarcopenic obesity is associated with decreased survival and increased therapy toxicity in cancer patients [5–10], whereas FFM loss is related to decreased survival, a negative clinical outcome, increased health care costs , and impaired overall health, functional capacities, and quality of life [4–11]. Therefore, the detection and treatment of FFM loss is a major issue of public health and health costs .
Weight loss and the body mass index (BMI) lack sensitivity to detect FFM loss . In this review, we support the systematic assessment of FFM with a method of body composition evaluation in order to improve the detection, management, and follow-up of undernutrition. Such an approach should in turn reduce the clinical and functional consequences of diseases in the setting of a cost- effective medico-economic approach (fig. 1). We discuss the main applications of body composition evaluation in clinical practice (fig. 2).
Fig. 1. Conceptualization of the expected impact of early use of body composition for the screening of fat-free loss and under-nutrition in sarcopenic overweight and obese subjects. An increased prevalence of overweight and obesity is observed in all Western and emerging countries. Simultaneously, the aging of the population, the reduction of the level of physical activity, and the higher prevalence of chronic dis- eases and cancer increased the number of patients with or at risk of FFM impairment, i.e. sarcopenia. Thus, more patients are presenting with ‘sarcopenic over- weight or obesity’. In these patients, evaluation of nutritional status using anthropometric methods, i.e. weight loss and calculation of BMI, is not sensitive enough to detect FFM impairment. As a result, undernutrition is not detected, worsens, and negatively impacts morbidity, mortality, LOS, length of recovery, quality of life, and health care costs. On the contrary, in patients with ‘sarcopenic overweight or obesity’, early screening of undernutrition with a dedicated method of body composition evaluation would allow early initiation of nutritional support and, in turn, improvements of nutritional status and clinical outcome.
Rationale for a New Strategy for the Screening of Undernutrition
Screening of Undernutrition Is Insufficient
Body composition evaluation is a valuable technique to assess nutritional status. Firstly, it gives an evaluation of nutritional status through the assessment of FFM. Secondly, by measuring FFM and phase angle with BIA, it allows evaluation of the disease prognosis and outcome.
BIA measures the phase angle . A low phase angle is related to survival in oncology [46–50], HIV infection/ AIDS , amyotrophic lateral sclerosis , geriatrics , peritoneal dialysis , and cirrhosis . The phase angle threshold associated with reduced survival is variable: less than 2.5 degrees in amyotrophic lateral sclerosis patients , 3.5 degrees in geriatric patients , from less than 1.65 to 5.6 degrees in oncology patients [47–50], and 5.4 degrees in cirrhotic patients . The phase angle is also associated with the severity of lymphopenia in AIDS , and with the risk of postoperative complications among gastrointestinal surgical patients . The relation of phase angle with prognosis and disease severity reinforces the interest in using BIA for the clinical management of patients with chronic diseases at high risk of undernutrition and FFM loss.
In summary, FFM loss or a low phase angle is related to mortality in patients with chronic diseases, cancer (in- cluding obesity cancer patients), and elderly patients in long-stay facilities. A low FFM and an increased FM are associated with an increased LOS in adult hospitalized patients. The relation between FFM loss and clinical out- come is clearly shown in patients with sarcopenic obesity. In these patients, as the sensitivity of BMI for detecting FFM loss is strongly reduced, body composition evalua- tion appears to be the method of choice to detect under- nutrition in routine practice. Overall, the association between body composition, phase angle, and clinical outcome reinforces the pertinence of using a body com- position evaluation in clinical practice.
Compared with other techniques of body composition evaluation, the lack of reproducibility and sensitivity of the 4-skinfold method limits its use for the accurate measurement of body composition in clinical practice [33, 34]. However, in patients with cirrhosis [39, 40], COPD , and HIV infection , measurement of the mid- arm muscle circumference could be used to assess sarcopenia and disease-related prognosis. DEXA allows non- invasive direct measurement of the three major components of body composition. The measurement of bone mineral tissue by DEXA is used in clinical practice for the diagnosis and follow-up of osteoporosis. As the clinical conditions complicated by osteoporosis are often associated with undernutrition, i.e. elderly women, patients with organ insufficiencies, COPD , inflammatory bowel diseases, and celiac disease, DEXA could be of the utmost interest for the follow-up of both osteoporosis and nutritional status. However, the combined evaluation of bone mineral density and nutritional status is difficult to implement in clinical practice because the reduced accessibility of DEXA makes it impossible to be performed in all nutritionally at-risk or malnourished patients. The principles and clinical utilization of BIA have been largely described in two ESPEN position papers [45, 66]. BIA is based on the capacity of hydrated tissues to conduct electrical energy. The measurement of total body impedance allows estimation of total body water by assuming that total body water is constant. From total body water, validated equations allow the calculation of FFM and FM , which are interpreted according to reference values . BIA is the only technique which allows calculation of the phase angle, which is correlated with the prognosis of various diseases. BIA equations are valid for: COPD ; AIDS wasting ; heart, lung, and liver transplantation ; anorexia nervosa  patients, and elderly subjects . However, no BIA-specific equations have been validated in patients with extreme BMI (less than 17 and higher than 33.8) and dehydration or fluid overload [45, 66]. Nevertheless, because of its simplicity, low cost, quickness of use at bedside, and high interoperator reproducibility, BIA appears to be the technique of choice for the systematic and repeated evaluation of FFM in clinical practice, particularly at hospital admission and in chronic diseases. Finally, through written and objective re- ports, the wider use of BIA should allow improvement of the traceability of nutritional evaluation and an increase in the recognition of nutritional care by the health authorities. Recently, several data have suggested that CT images targeted on the 3rd lumbar vertebra (L3) could strongly predict whole-body fat and FFM in cancer patients, as compared with DEXA [7, 67]. Interestingly, the evaluation of body composition by CT presents great practical significance due to its routine use in patient diagnosis, staging, and follow-up. L3-targeted CT images evaluate FFM by measuring the muscle cross-sectional area from L3 to the iliac crest by use of Hounsfield unit (HU) thresholds (–29 to +150) [5, 7]. The muscles included in the calculation of the muscle cross-sectional area are psoas, paraspinal muscles (erector spinae, quadratus lumborum), and abdominal wall muscles (transversus abdominis, external and internal obliques, rectus ab- dominis) . CT also provided detail on specific muscles, adipose tissues, and organs not provided by DEXA or BIA. L3-targeted CT images could be theoretically per- formed solely, since they result in X-ray exposition similar to that of a chest radiography.
In summary, DEXA, BIA, and L3-targeted CT images could all measure body composition accurately. The technique selection will depend on the clinical context, hard- ware, and knowledge availability. Body composition evaluation by DEXA should be performed in patients having a routine assessment of bone mineral density. Also, analysis of L3-targeted CT is the method of choice for body composition evaluation in cancer patients. Body composition evaluation should also be done for every abdominal CT performed in patients who are nutritionally at risk or undernourished. Because of its simplicity of use, BIA could be widely implemented as a method of body com- position evaluation and follow-up in a great number of hospitalized and ambulatory patients. Future research will aim to determine whether a routine evaluation of body composition would allow early detection of the in- creased FFM catabolism related to critical illness .
In summary, the measurement of FFM should help ad- just the calculation of energy needs (expressed as kcal/kg FFM) and optimize nutritional support in critical cases other than anorexia nervosa.
In summary, body composition evaluation is of the utmost interest for the follow-up of nutritional support and its impact on body compartments.
In summary, measurement of FFM should be implemented in cancer patients treated with chemotherapy. Clinical studies are needed to demonstrate the importance of measuring body composition in patients treated with other medical treatments.
In other situations, BIA appears to be the simplest most reproducible and less expensive method, while DEXA, if feasible, remains the reference method for clinical practice. By allowing earlier management of undernutrition, body composition evaluation can contribute to reducing malnutrition-induced morbidity and mortality, improving the quality of life and, as a consequence, increasing the medico-economic benefits (fig. 1). The latter needs to be demonstrated. Moreover, based on a more scientific approach, i.e. allowing for printing reports, objective initial assessment and follow-up of nutritional status, and the adjustment of drug doses, body composition evaluation would contribute to a better recognition of the activities related to nutritional evaluation and care by the medical community, health care facilities, and health authorities (fig. 2).
Screening of undernutrition is insufficient to allow for optimal nutrition care. This is in part due to the lack of sensitivity of BMI and weight loss for detecting FFM loss in patients with chronic diseases. Methods of body com- position evaluation allow a quantitative measurement of FFM changes during the course of disease and could be used to detect FFM loss in the setting of an objective, systematic, and early undernutrition screening. FFM loss is closely related to impaired clinical outcomes, survival, and quality of life, as well as increased therapy toxicity in cancer patients. Thus, body composition evaluation should be integrated into clinical practice for the initial assessment, sequential follow-up of nutritional status, and the tailoring of nutritional and disease-specific therapies. Body composition evaluation could contribute to strengthening the role and credibility of nutrition in the global medical management, reducing the negative impact of malnutrition on the clinical outcome and quality of life, thereby increasing the overall medico-economic benefits.
R. Thibault and C. Pichard are supported by research grants from the public foundation Nutrition 2000 Plus.
Ronan Thibault and Claude Pichard declare no conflict of interest.
1 Pirlich M, Schutz T, Norman K, Gastell S,
Lübke HJ, Bischoff SC, Bolder U, Frieling
T, Güldenzoph H, Hahn K, Jauch KW,
Schindler K, Stein J, Volkert D, Weimann A,
Werner H, Wolf C, Zürcher G, Bauer P, Lochs
H: The German hospital malnutrition study.
Clin Nutr 2006;25:563–572.
2 Amaral TF, Matos LC, Tavares MM, Subtil
A, Martins R, Nazaré M, Sousa Pereira N:
The economic impact of disease-related malnutrition
at hospital admission. Clin Nutr
3 Pichard C, Kyle UG, Morabia A, Perrier A,
Vermeulen B, Unger P: Nutritional assessment:
lean body mass depletion at hospital
admission is associated with increased
length of stay. Am J Clin Nutr 2004;79:613–
4 Capuano G, Gentile PC, Bianciardi F, Tosti
M, Palladino A, Di Palma M: Prevalence and
influence of malnutrition on quality of life
and performance status in patients with locally
advanced head and neck cancer before
treatment. Support Care Cancer 2010;18:
5 Prado CM, Lieffers JR, McCargar LJ, Reiman
T, Sawyer MB, Martin L, Baracos VE: Prevalence
and clinical implications of sarcopenic
obesity in patients with solid tumours of the
respiratory and gastrointestinal tracts: a
population-based study. Lancet Oncol 2008;
6 Tan BHL, Birdsell LA, Martin L, Baracos VE,
Fearon KC: Sarcopenia in an overweight or
obese patient is an adverse prognostic factor
in pancreatic cancer. Clin Cancer Res 2009;
7 Baracos VE, Reiman T, Mourtzakis M,
Gioulbasanis I, Antoun S: Body composition
in patients with non-small cell lung cancer:
a contemporary view of cancer cachexia
with the use of computed tomography image
analysis. Am J Clin Nutr 2010;91(suppl):
8 Antoun S, Baracos VE, Birdsell L, Escudier
B, Sawyer MB: Low body mass index and sarcopenia
associated with dose-limiting toxicity
of sorafenib in patients with renal cell carcinoma.
Ann Oncol 2010;21:1594–1598
9 Prado CM, Baracos VE, McCargar LJ,
Mourtzakis M, Mulder KE, Reiman T, Butts
CA, Scarfe AG, Sawyer MB: Body composition
as an independent determinant of 5-fluorouracil-based
chemotherapy toxicity. Clin
Cancer Res 2007;13:3264–3268.
10 Prado CM, Baracos VE, McCargar LJ, Reiman
T, Mourtzakis M, Tonkin K, Mackey JR,
Koski S, Pituskin E, Sawyer MB: Sarcopenia
as a determinant of chemotherapy toxicity
and time to tumor progression in metastatic
breast cancer patients receiving capecitabine
treatment. Clin Cancer Res 2009;15:2920–
11 Hofhuis JG, Spronk PE, van Stel HF, Schrijvers
GJ, Rommes JH, Bakker J: The impact of
critical illness on perceived health-related
quality of life during ICU treatment, hospital
stay, and after hospital discharge: a longterm
follow-up study. Chest 2008;133:377–
12 Guest JF, Panca M, Baeyens JP, de Man F,
Ljungqvist O, Pichard C, Wait S, Wilson L:
Health economic impact of managing patients
following a community-based diagnosis
of malnutrition in the UK. Clin Nutr 2011;
13 Kyle UG, Morabia A, Slosman DO, Mensi N,
Unger P, Pichard C: Contribution of body
composition to nutritional assessment at
hospital admission in 995 patients: a controlled
population study. Br J Nutr 2001;86:
14 Kondrup J, Allison SP, Elia M; Vellas B,
Plauth M: Educational and Clinical Practice
Committee, European Society of Parenteral
and Enteral Nutrition (ESPEN): ESPEN
guidelines for nutrition screening 2002. Clin
15 Haute Autorité de Santé: IPAQSS: informations.
16 World Health Organization: Obesity and
overweight: fact sheet No. 311. 2011. http://
17 Thibault R, Chikhi M, Clerc A, Darmon P,
Chopard P, Picard-Kossovsky M, Genton L,
Pichard C: Assessment of food intake in hospitalised
patients: a 10 year-comparative
study of a prospective hospital survey. Clin
18 Stenholm S, Harris TB, Rantanen T, Visser
M, Kritchevsky SB, Ferrucci L: Sarcopenic
obesity: definition, cause and consequences.
Curr Opin Clin Nutr Metab Care 2008;11:
19 Pichard C, Kyle UG: Body composition measurements
during wasting diseases. Curr
Opin Clin Nutr Metab Care 1998;1:357–361.
20 Wang ZM, Pierson RN Jr, Heymsfield SB:
The five-level model: a new approach to organizing
body-composition research. Am J
Clin Nutr 1992;56:19–28.
21 Schols AM, Broekhuizen R, Weling-Scheepers
CA, Wouters EF: Body composition and
mortality in chronic obstructive pulmonary
disease. Am J Clin Nutr 2005;82:53–59.
22 Slinde F, Gronberg A, Engstrom CP, Rossander-Hulthen
L, Larsson S: Body composition
by bioelectrical impedance predicts
mortality in chronic obstructive pulmonary
disease patients. Respir Med 2005;99:1004–
23 Vestbo J, Prescott E, Almdal T, Dahl M, Nordestgaard
BG, Andersen T, Sorensen TI,
Lange P: Body mass, fat-free body mass, and
prognosis in patients with chronic obstructive
pulmonary disease from a random population
sample: findings from the Copenhagen
City Heart Study. Am J Respir Crit Care
24 Segall L, Mardare NG, Ungureanu S, Busuioc
M, Nistor I, Enache R, Marian S, Covic A:
Nutritional status evaluation and survival in
haemodialysis patients in one centre from
Romania. Nephrol Dial Transplant 2009;24:
25 Beddhu S, Pappas LM, Ramkumar N, Samore
M: Effects of body size and body composition
on survival in hemodialysis patients. J
Am Soc Nephrol 2003;14:2366–2372.
26 Fürstenberg A, Davenport A: Assessment
of body composition in peritoneal dialysis
patients using bioelectrical impedance and
dual-energy X-ray absorptiometry. Am J
27 Futter JE, Cleland JG, Clark AL: Body mass
indices and outcome in patients with chronic
heart failure. Eur J Heart Fail 2011;13:207–
28 Marin B, Desport JC, Kajeu P, Jesus P, Nicolaud
B, Nicol M, Preux PM, Couratier P: Alteration
of nutritional status at diagnosis is
a prognostic factor for survival of amyotrophic
lateral sclerosis patients. J Neurol
Neurosurg Psychiatry 2011;82:628–634.
29 Janiszewski PM, Oeffinger KC, Church TS,
Dunn AL, Eshelman DA, Victor RG, Brooks
S, Turoff AJ, Sinclair E, Murray JC, Bashore
L, Ross R: Abdominal obesity, liver fat, and
muscle composition in survivors of childhood
acute lymphoblastic leukemia. J Clin
Endocrinol Metab 2007;92:3816–3821.
30 Wagner D, Adunka C, Kniepeiss D, Jakoby
E, Schaffellner S, Kandlbauer M, Fahrleitner-Pammer
A, Roller RE, Kornprat P, Müller
H, Iberer F, Tscheliessnigg KH: Serum albumin,
subjective global assessment, body
mass index and the bioimpedance analysis in
the assessment of malnutrition in patients up
to 15 years after liver transplantation. Clin
31 Kimyagarov S, Klid R, Levenkrohn S, Fleissig
Y, Kopel B, Arad M, Adunsky A: Body
mass index (BMI), body composition and
mortality of nursing home elderly residents.
Arch Gerontol Geriatr 2010;51:227–230.
32 Buffa R, Mereu RM, Putzu PF, Floris G,
Marini E: Bioelectrical impedance vector
analysis detects low body cell mass and dehydration
in patients with Alzheimer’s disease.
J Nutr Health Aging 2010;14:823–827.
33 Schols AM, Wouters EF, Soeters PB, Westerterp
KR: Body composition by bioelectricalimpedance
analysis compared with deuterium
dilution and skinfold anthropometry in
patients with chronic obstructive pulmonary
disease. Am J Clin Nutr 1991;53:421–424.
34 Thibault R, Le Gallic E, Picard-Kossovsky
M, Darmaun D, Chambellan A: Assessment
of nutritional status and body composition
in patients with COPD: comparison of several
methods (in French). Rev Mal Respir
35 Kyle UG, Janssens JP, Rochat T, Raguso CA,
Pichard C: Body composition in patients
with chronic hypercapnic respiratory failure.
Respir Med 2006;100:244–252.
36 Rieken R, van Goudoever JB, Schierbeek H,
Willemsen SP, Calis EA, Tibboel D, Evenhuis
HM, Penning C: Measuring body composition
and energy expenditure in children with
severe neurologic impairment and intellectual
disability. Am J Clin Nutr 2011;94:759–
37 Avram MM, Fein PA, Borawski C, Chattopadhyay
J, Matza B: Extracellular mass/body
cell mass ratio is an independent predictor of
survival in peritoneal dialysis patients. Kidney
Int Suppl 2010;117:S37–S40.
38 Frisancho AR: New norms of upper limb fat
and muscle areas for assessment of nutritional
status. Am J Clin Nutr 1981;34:2540–2545.
39 Caregaro L, Alberino F, Amodio P, Merkel C,
Bolognesi M, Angeli P, Gatta A: Malnutrition
in alcoholic and virus-related cirrhosis.
Am J Clin Nutr l996;63:602–609.
40 Alberino F, Gatta A, Amodio P, Merkel C, Di
Pascoli L, Boffo G, Caregaro L: Nutrition and
survival in patients with liver cirrhosis. Nutrition
41 Liu E, Spiegelman D, Semu H, Hawkins C,
Chalamilla G, Aveika A, Nyamsangia S,
Mehta S, Mtasiwa D, Fawzi W: Nutritional
status and mortality among HIV-infected
patients receiving antiretroviral therapy in
Tanzania. J Infect Dis 2011;204:282–290.
42 Soler-Cataluna JJ, Sanchez-Sanchez L, Martinez-Garcia
MA, Sanchez PR, Salcedo E,
Navarro M: Mid-arm muscle area is a better
predictor of mortality than body mass index
in COPD. Chest 2005;128:2108–2115.
43 Marquis K, Debigaré R, Lacasse Y, LeBlanc P,
Jobin J, Carrier G, Maltais F: Midthigh muscle
cross-sectional area is a better predictor
of mortality than body mass index in patients
with chronic obstructive pulmonary
disease. Am J Respir Crit Care Med 2002;15;
44 Kyle UG, Pirlich M, Lochs H, Schuetz T, Pichard
C: Increased length of hospital stay in
underweight and overweight patients at hospital
admission: a controlled population
study. Clin Nutr 2005;24:133–142.
45 Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg
P, Elia M, Gómez JM, Heitmann
BL, Kent-Smith L, Melchior JC, Pirlich M,
Scharfetter H, Schols AM, Pichard C, Composition
of the ESPEN Working Group. Bioelectrical
impedance analysis. 1. Review of
principles and methods. Clin Nutr 2004;23:
46 Santarpia L, Marra M, Montagnese C, Alfonsi
L, Pasanisi F, Contaldo F: Prognostic
significance of bioelectrical impedance
phase angle in advanced cancer: preliminary
observations. Nutrition 2009;25:930–931.
47 Gupta D, Lammersfeld CA, Vashi PG, King
J, Dahlk SL, Grutsch JF, Lis CG: Bioelectrical
impedance phase angle in clinical practice:
implications for prognosis in stage IIIB and
IV non-small cell lung cancer. BMC Cancer
48 Gupta D, Lis CG, Dahlk SL, Vashi PG,
Grutsch JF, Lammersfeld CA: Bioelectrical
impedance phase angle as a prognostic indicator
in advanced pancreatic cancer. Br J
49 Gupta D, Lammersfeld CA, Burrows JL,
Dahlk SL, Vashi PG, Grutsch JF, Hoffman S,
Lis CG: Bioelectrical impedance phase angle
in clinical practice: implications for prognosis
in advanced colorectal cancer. Am J Clin
50 Paiva SI, Borges LR, Halpern-Silveira D, Assunção
MC, Barros AJ, Gonzalez MC: Standardized
phase angle from bioelectrical impedance
analysis as prognostic factor for
survival in patients with cancer. Support
Care Cancer 2010;19:187–192.
51 Schwenk A, Beisenherz A, Römer K, Kremer
G, Salzberger B, Elia M: Phase angle from
bioelectrical impedance analysis remains an
independent predictive marker in HIV-infected
patients in the era of highly active antiretroviral
treatment. Am J Clin Nutr 2000;
52 Desport JC, Marin B, Funalot B, Preux PM,
Couratier P: Phase angle is a prognostic factor
for survival in amyotrophic lateral sclerosis.
Amyotroph Lateral Scler 2008;9:273–
53 Wirth R, Volkert D, Rösler A, Sieber CC,
Bauer JM: Bioelectric impedance phase angle
is associated with hospital mortality of
geriatric patients. Arch Gerontol Geriatr
54 Mushnick R, Fein PA, Mittman N, Goel N,
Chattopadhyay J, Avram MM: Relationship
of bioelectrical impedance parameters to nutrition
and survival in peritoneal dialysis patients.
Kidney Int Suppl 2003;87:S53–S56.
55 Selberg O, Selberg D: Norms and correlates
of bioimpedance phase angle in healthy human
subjects, hospitalized patients, and patients
with liver cirrhosis. Eur J Appl Physiol
56 Shah S, Whalen C, Kotler DP, Mayanja H,
Namale A, Melikian G, Mugerwa R, Semba
RD: Severity of human immunodeficiency
virus infection is associated with decreased
phase angle, fat mass and body cell mass in
adults with pulmonary tuberculosis infection
in Uganda. J Nutr 2001;131:2843–2847.
57 Barbosa-Silva MC, Barros AJ: Bioelectric impedance
and individual characteristics as
prognostic factors for post-operative complications.
Clin Nutr 2005;24:830–838.
58 Durnin JV, Womersley J: Body fat assessed
from total body density and its estimation
from skinfold thickness: measurements on
481 men and women aged from 16 to 72
years. Br J Nutr 1974;32:77–97.
59 Hill GL: Body composition research: implications
for the practice of clinical nutrition.
JPEN J Parenter Enter Nutr 1992;16:197–218.
60 Pierson RN Jr, Wang J, Thornton JC, Van
Itallie TB, Colt EW: Body potassium by fourpi
40K counting: an anthropometric correction.
Am J Physiol 1984;246:F234–F239.
61 Sohlström A, Forsum E: Changes in total
body fat during the human reproductive cycle
as assessed by magnetic resonance imaging,
body water dilution, and skinfold thickness:
a comparison of methods. Am J Clin
62 Leonard CM, Roza MA, Barr RD, Webber
CE: Reproducibility of DXA measurements
of bone mineral density and body composition
in children. Pediatr Radiol 2009;39:148–
63 Genton L, Karsegard VL, Zawadynski S, Kyle
UG, Pichard C, Golay A, Hans DB: Comparison
of body weight and composition measured
by two different dual energy X-ray absorptiometry
devices and three acquisition
modes in obese women. Clin Nutr 2006;25:
64 Jaffrin MY: Body composition determination
by bioimpedance: an update. Curr Opin
Clin Nutr Metab Care 2009;12:482–486.
65 Kyle UG, Pichard C, Rochat T, Slosman DO,
Fitting JW, Thiebaud D: New bioelectrical
impedance formula for patients with respiratory
insufficiency: comparison to dual-energy
X-ray absorptiometry. Eur Respir J 1998;
66 Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg
P, Elia M, Manuel Gómez J, Lilienthal
Heitmann B, Kent-Smith L, Melchior
JC, Pirlich M, Scharfetter H, Schols AMWJ,
Pichard C, ESPEN: Bioelectrical impedance
analysis. 2. Utilization in clinical practice.
Clin Nutr 2004;23:1430–1453.
67 Mourtzakis M, Prado CM, Lieffers JR, Reiman
T, McCargar LJ, Baracos VE: A practical
and precise approach to quantification of
body composition in cancer patients using
computed tomography images acquired during
routine care. Appl Physiol Nutr Metab
68 Bolton CE, Ionescu AA, Shiels KM, Pettit RJ,
Edwards PH, Stone MD, Nixon LS, Evans
WD, Griffiths TL, Shale DJ: Associated loss
of fat-free mass and bone mineral density in
chronic obstructive pulmonary disease. Am
J Respir Crit Care Med 2004;170:1286–1293.
69 Kyle UG, Genton L, Karsegard L, Slosman
DO, Pichard C: Single prediction equation
for bioelectrical impedance analysis in
adults aged 20–94 years. Nutrition 2001;17:
70 Kyle UG, Genton L, Slosman DO, Pichard C:
Fat-free and fat mass percentiles in 5,225
healthy subjects aged 15 to 98 years. Nutrition
71 Kotler DP, Burastero S, Wang J, Pierson RN
Jr: Prediction of body cell mass, fat-free
mass, and total body water with bioelectrical
impedance analysis: effects of race, sex, and
disease. Am J Clin Nutr 1996;64:489S–497S.
72 Kyle UG, Genton L, Mentha G, Nicod L, Slosman
DO, Pichard C: Reliable bioelectrical
impedance analysis estimate of fat-free mass
in liver, lung, and heart transplant patients.
JPEN J Parenter Enteral Nutr 2001;25:45–51.
73 Mattar L, Godart N, Melchior JC, Falissard
B, Kolta S, Ringuenet D, Vindreau C, Nordon
C, Blanchet C, Pichard C: Underweight
patients with anorexia nervosa: comparison
of bioelectrical impedance analysis using
five equations to dual X-ray absorptiometry.
Clin Nutr 2011, E-pub ahead of print.
74 Genton L, Karsegard VL, Kyle UG, Hans DB,
Michel JP, Pichard C: Comparison of four
bioelectrical impedance analysis formulas in
healthy elderly subjects. Gerontology 2001;
75 Robert S, Zarowitz BJ, Hyzy R, Eichenhorn
M, Peterson EL, Popovich J Jr: Bioelectrical
impedance assessment of nutritional status
in critically ill patients. Am J Clin Nutr 1993;
76 Pichard C, Kyle UG, Slosman DO, Penalosa
B: Energy expenditure in anorexia nervosa:
can fat-free mass as measured by bioelectrical
impedance predict energy expenditure in
hospitalized patients? Clin Nutr 1996;15:
77 Kreymann KG, Berger MM, Deutz NE, Hiesmayr
M, Jolliet P, Kazandjiev G, Nitenberg
G, van den Berghe G, Wernerman J, DGEM
(German Society for Nutritional Medicine),
Ebner C, Hartl W, Heymann C, Spies C, ESPEN:
ESPEN guidelines on enteral nutrition:
intensive care. Clin Nutr 2006;25:210–223.
78 Singer P, Berger MM, van den Berghe G, Biolo
G, Calder P, Forbes A, Griffiths R, Kreyman
G, Leverve X, Pichard C, ESPEN: ESPEN
guidelines on parenteral nutrition: intensive
care. Clin Nutr 2009;28:387–400.
79 Magnuson B, Peppard A, Auer Flomenhoft
D: Hypocaloric considerations in patients
with potentially hypometabolic disease
states. Nutr Clin Pract 2011;26:253–260.
80 Rigaud D, Boulier A, Tallonneau I, Brindisi
MC, Rozen R: Body fluid retention and body
weight change in anorexia nervosa patients
during refeeding. Clin Nutr 2010;29:749–
81 Kyle UG, Chalandon Y, Miralbell R, Karsegard
VL, Hans D, Trombetti A, Rizzoli R,
Helg C, Pichard C: Longitudinal follow-up of
body composition in hematopoietic stem cell
transplant patients. Bone Marrow Transplant
82 Pison CM, Cano NJ, Cherion C, Caron F,
Court-Fortune I, Antonini M, GonzalezBermejo
J, Meziane L, Molano LC, Janssens
JP, Costes F, Wuyam B, Similowski T, Melloni
B, Hayot M, Augustin J, Tardif C,
Lejeune H, Roth H, Pichard C, the IRAD Investigators:
Multimodal nutritional rehabilitation
improves clinical outcomes of malnourished
patients with chronic respiratory
failure: a controlled randomised trial. Thorax
83 Pichard C, Kyle U, Chevrolet JC, Jolliet P,
Slosman D, Mensi N, Temler E, Ricou B: Lack
of effects of recombinant growth hormone
on muscle function in patients requiring
prolonged mechanical ventilation: a prospective,
randomized, controlled study. Crit
Care Med 1996;24:403–413.
84 Pichard C, Kyle UG, Jolliet P, Slosman DO,
Rochat T, Nicod L, Romand J, Mensi N,
Chevrolet JC: Treatment of cachexia with recombinant
growth hormone in a patient before
lung transplantation: a case report. Crit
Care Med 1999;27:1639–1642.
85 Leslie WD, Miller N, Rogala L, Bernstein
CN: Body mass and composition affect bone
density in recently diagnosed inflammatory
bowel disease: the Manitoba IBD Cohort
Study. Inflamm Bowel Dis 2009;15:39–46.
86 van der Meij BS, Langius JA, Smit EF,
Spreeuwenberg MD, von Blomberg BM,
Heijboer AC, Paul MA, van Leeuwen PA:
Oral nutritional supplements containing (n-
3) polyunsaturated fatty acids affect the nutritional
status of patients with stage III nonsmall
cell lung cancer during multimodality
treatment. J Nutr 2010;140:1774–1780.
87 Ryan AM, Reynolds JV, Healy L, Byrne M,
Moore J, Brannelly N, McHugh A, McCormack
D, Flood P: Enteral nutrition enriched
with eicosapentaenoic acid (EPA) preserves
lean body mass following esophageal cancer
surgery: results of a double-blinded randomized
controlled trial. Ann Surg 2009;249:
88 Ndekha MJ, Oosterhout JJ, Zijlstra EE, Manary
M, Saloojee H, Manary MJ: Supplementary
feeding with either ready-to-use fortified
spread or corn-soy blend in wasted
adults starting antiretroviral therapy in Malawi:
randomised, investigator blinded, controlled
trial. BMJ 2009;338:b1867–b1875.
89 Ha L, Hauge T, Iversen PO: Body composition
in older acute stroke patients after treatment
with individualized, nutritional supplementation
while in hospital. BMC Geriatrics
90 Genton L, Karsegard VL, Chevalley T, Kossovsky
MP, Darmon P, Pichard C: Body
composition changes over 9 years in
healthy elderly subjects and impact of physical
activity. Clin Nutr 2011;30:436–442.
91 Reid CL, Murgatroyd PR, Wright A, Menon
DK: Quantification of lean and fat tissue repletion
following critical illness: a case report.
Crit Care 2008;12:R79.
92 Antoun S, Birdsel Ll, Sawyer MB, Venner P,
Escudier B, Baracos VE: Association of skeletal
muscle wasting with treatment with
sorafenib in patients with advanced renal
cell carcinoma: results from a placebo-controlled
study. J Clin Oncol 2010;28:1054–
93 Prado CM, Antoun S, Sawyer MB, Baracos
VE: Two faces of drug therapy in cancer:
drug-related lean tissue loss and its adverse
consequences to survival and toxicity. Curr
Opin Clin Nutr Metab Care 2011;14:250–
94 Schutz Y, Kyle UG, Pichard C: Fat-free mass
index and fat mass index percentiles in Caucasians
aged 18–98 y. Int J Obes 2002;26:
95 Kyle UG, Schutz Y, Dupertuis YM, Pichard
C: Body composition interpretation: contributions
of the fat-free mass index and the
body fat mass index. Nutrition 2003;19:597–
96 Kyle UG, Piccoli A, Pichard C: Body composition
measurements: interpretation finally
made easy for clinical use. Curr Opin Clin
Nutr Metab Care 2003;6:387–393.
Minimally invasive surgical procedures can be used to treat spinal compression fractures. These procedures are… Read More