A European Medicines Agency panel said on Friday it recommended granting marketing approval to Sanofi and Regeneron’s experimental drug to treat rheumatoid arthritis.
The Committee for Medicinal Products for Human Use gave a positive opinion on the drug, Kevzara, citing its ability to reduce the signs and symptoms of rheumatoid arthritis.
Sarilumab, the active substance of Kevzara, a treatment for adult patients with moderate to severe rheumatoid arthritis, works by blocking a protein called IL-6, which is associated with inflammation.
The panel’s opinion will now be reviewed by the EMA.
In October, U.S. regulators declined to approve sarilumab because of manufacturing deficiencies at a Sanofi plant in France.
Regeneron said in February that it was planning to resubmit a marketing application to the U.S. Food and Drug Administration for sarilumab.
The drug has already been approved by Canadian health regulators to treat rheumatoid arthritis.
Researchers have found that a diet high in saturated fat is a prime suspect in the onset of osteoarthritis after finding that it changes the composition of cartilage, especially in the weight-bearing joints of the hip and knee.
Our findings suggest that it’s not wear and tear but diet that has a lot to do with the onset of osteoarthritis, said lead researcher Professor Yin Xiao.
In possibly the first study to investigate the link between osteoarthritis and common dietary fatty acids, scientists at the Queensland University of Technology studied the effects of diets rich in a variety of fatty acids, found in butter, coconut oil, palm oil, and animal fat, and simple carbohydrates. Simple carbs found in sugar, corn syrup, and high-fructose corn syrup and the combination of high-fat, high-carb foods are commonly known as “junk food.”
“The main function of cartilage is to seal the bone ends in a joint and absorb pressure on the bones during weight-bearing mov
Eben Britton is a man who understands pain. Within his six-year NFL playing career as an offensive lineman for the Jacksonville Jaguars and Chicago Bears, he experienced major and minor injuries alike, including a torn labrum, a hamstring injury, a herniated disc resulting in sciatica that still ails him to this day. “I can’t feel my right foot on the ground,” he tells me.
Compounding these injuries is the game of football itself, America’s most bone-crushing sport. The crunching tackles and successful blows devastate the body over time. How football addles the brain is a topic the league would prefer not to discuss. “It’s a violent game that I personally don’t think humans are supposed to play,” said Doug Whaley, the Buffalo Bill general manager, last year.
Rheumatoid arthritis is the most prominent autoimmune arthritis. It is caused by a defective immune system that causes your defense system to target your joint linings. It affects the wrist and small joints of your hands, including the knuckles, other joints in your fingers and can eventually spread to your knees too.
It is considered one of the most disabling forms of arthritis as it affects both sides of the body, making it different from other forms of arthritis. It can also affect skin, eyes, lungs, heart, blood and even your nerves which is why it is one of the most feared forms of arthritis.
Over the years, several ways of treating rheumatoid arthritis have been discovered. Although there is still no cure for the condition, the treatment can significantly heal those that are newly diagnosed and can slow down the process that in the patients that have been suffering from the condition for a while.
When your immune system attacks your own body, certain chemicals