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Functional Medicine®

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Functional Medicine Explained

How SAG Helps The Body

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Do you feel:

  • Agitated, easily upset, or have tremors?
  • Afternoon fatigues?
  • Mental sluggishness?
  • Tired?
  • Stressed out?

If you are feeling any of these situations, then you might be experiencing low levels of glutathione, why not add some S-acetyl glutathione into your body.

Glutathione

When glutathione is decreased in the body, it is known as glutathione deficiency or GSH. It is a tripeptide that is consist of L-glutamine, L-cysteine, and glycine while also being functional in the systems of the body. The biosynthesis of glutathione can be affected by some factors such as biochemical individuality or dietary factors. Another factor that can affect glutathione in the body is chronic oxidative stress. Chronic oxidative stress can deplete cellular glutathione in the body, causing it to develop inflammation and dysfunction to its organ systems.

There are ways to boost glutathione levels in the body since these nutrients and supplements are the precursors to glutathione. They consist of whey protein, vitamin C, and glutamine, and they can help raise the glutathione levels in the body to prevent inflammation and disruptive factors that can cause harm to the body; however, the results are inconsistent and need further research. Studies stated that biological individuality is different to every type of body since it is equivalent and can metabolize the precursor nutrients and supplements to the body.

Why Not Distribute Pure Glutathione?

Sadly though, when a person takes glutathione in an oral form, the results are unpleasant. When the person takes glutathione in the mouth, the oral dosage is oxidized instantly, before being absorbed into the body, thus leaving a foul smell. Taking glutathione in a vegetable capsule can help the individual receive glutathione without it being oxidized.

Many formulas can deliver a unique preparation to glutathione that can overcome the limitations it faces. Studies show that S-acetyl glutathione is stable enough to go through the intestinal walls and deposit the necessary nutrients into the body. With S-acetyl glutathione being consumed orally, it can increase the total glutathione and the percent-reduced glutathione so it can be beneficial for the body. With percent-reduced glutathione, it has a very significant biomarker for excellent status for a functional body.

The Mechanics of SAG Absorption

S-acetyl glutathione or SAG is a lipid-like compound that is taken by intact chylomicrons in the gut. The bond from this compound is placed into its thiol group that helps prevents oxidations in the body and allows molecules to pass into the cell walls after being absorbed into the gut. What happens is that the bond is cleaved by non-specific enzymes and helps prevent the breakdown of glutathione, while S-acetyl glutathione does not need expenditures to be cleaved once it crosses the cell walls in the body.

SAG Antioxidant Activity

Since glutathione helps tissue and organ functions throughout the body, it plays a critical role by protecting it from a variety of factors like, for example, oxidative stress, while also maintain cellular functions and supporting a healthy immune system. Studies show that many factors can increase oxidative stress exposure and adding insults to the body, therefore increasing the cellular consumption of the nutrients like glutathione, which provides antioxidant activity. When this happens, it leads to the result of a fiery cycle of oxidative stress and challenges detoxification to the body. Research states that complete biotransformation and protecting the body from oxidative stress is essential for the body to maintain cellular integrity and tissue health.

Benefits of Maintaining Healthy Glutathione Levels

There is plenty of information that is related to cellular health that has been surfaced. Research states that the mitochondria, which is the energy-producing powerhouse cell, has a role in being the primary functional cellular site for consuming oxygen and ROS (reactive oxygen species).  Studies show that S-acetyl glutathione can cross the membranes of the mitochondria by increasing the organ’s activity and minimizing ROS in the body. When ROS is reduced in the body, it can maintain the mitochondrial integrity and its function, while improving its health for the body to function correctly.

Studies show that S-acetyl glutathione can decrease TNF-alpha, NF-kappa beta, and F-2 isoprostane enzymes in the body. Additional studies show that there is a large amount of evidence that intracellular glutathione levels in macrophages can influence the Th1/Th2 cytokine pattern and can help promote a well-balanced immune reaction to the body.

Conclusion

Glutathione is an essential amino acid that is produced in the body. When there are low levels of glutathione in the body, S-acetyl glutathione can assist in maintaining those levels and by making sure that oxidative stress does not reach full capacity in the body to cause significant damage. Some products can provide more excellent stability, bioavailability, and digestive comfort for anyone who might be sensitive to N-acetyl L-cysteine.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Anderson, Michelle F, et al. “Glutathione Monoethylester Prevents Mitochondrial Glutathione Depletion during Focal Cerebral Ischemia.” Neurochemistry International, Pergamon, 20 June 2003, www.sciencedirect.com/science/article/abs/pii/S0197018603001335?via%3Dihub.

Ballatori, Nazzareno, et al. “Glutathione Dysregulation and the Etiology and Progression of Human Diseases.” Biological Chemistry, U.S. National Library of Medicine, Mar. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2756154/.

Fraternale, A., et al. “Antiviral and Immunomodulatory Properties of New Pro-Glutathione (GSH) Molecules.” Http://Www.eurekaselect.com, 31 May, 2006, www.eurekaselect.com/56205/article.

Kretzschmar, M. “Regulation of Hepatic Glutathione Metabolism and Its Role in Hepatotoxicity.” Experimental and Toxicologic Pathology, Urban & Fischer, 3 Nov. 2011, www.sciencedirect.com/science/article/abs/pii/S0940299396800546?via%3Dihub.

Locigno, Roberto, et al. “S-Acetyl-Glutathione Selectively Induces Apoptosis in Human Lymphoma Cells through a GSH-Independent Mechanism.” International Journal of Oncology, U.S. National Library of Medicine, Jan. 2002, www.ncbi.nlm.nih.gov/pubmed/11743644.

Lomaestro, Ben M, and Margaret Malone. “Glutathione in Health and Disease: Pharmacotherapeutic Issues – Ben M Lomaestro, Margaret Malone, 1995.” SAGE Journals, 1 Dec. 1995, journals.sagepub.com/doi/10.1177/106002809502901213.

Richman, PG, and A Meister. “Regulation of Gamma-Glutamyl-Cysteine Synthetase by Nonallosteric Feedback Inhibition by Glutathione.” The Journal of Biological Chemistry, U.S. National Library of Medicine, 25 Feb. 1975, www.ncbi.nlm.nih.gov/pubmed/1112810.

Vogel, Jens-Uwe, et al. “Effects of S-Acetylglutathione in Cell and Animal Model of Herpes Simplex Virus Type 1 Infection.” SpringerLink, Springer-Verlag, 18 Nov. 2003, link.springer.com/article/10.1007%2Fs00430-003-0212-z.

Whelan, Corey. “Glutathione Benefits.” Healthline, 21 Nov. 2017, www.healthline.com/health/glutathione-benefits.

Dr. Alex Jimenez D.C.,C.C.S.T

Welcome-Bienvenido's to our blog. We focus on treating severe spinal disabilities and injuries. We also treat Sciatica, Neck and Back Pain, Whiplash, Headaches, Knee Injuries, Sport Injuries, Dizziness, Poor Sleep, Arthritis. We use advanced proven therapies focused on optimal mobility, health, fitness, and structural conditioning. We use Individualized Diet Plans, Specialized Chiropractic Techniques, Mobility-Agility Training, Adapted Cross-Fit Protocols and the "PUSH System" to treat patients suffering from various injuries and health problems. If you would like to learn more about a Doctor of Chiropractic who uses advanced progressive techniques to facilitate complete physical health, please connect with me. We a focus on simplicity to help restore mobility and recovery. I'd love to see you. Connect!

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