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Whiplash is one of the most prevalent types of injuries resulting from an automobile accident, most commonly during rear-end auto collisions. However, whiplash-associated disorders can develop due to a variety of other circumstances, including sports injuries, amusement park rides or physical abuse. Whiplash occurs when the soft tissues of the neck, such as the muscles, tendons and ligaments, extend beyond their natural range of motion because of a sudden back-and-forth movement of the head. Furthermore, the sheer force of an impact can stretch and even tear the complex structures surrounding the cervical spine.
The symptoms of whiplash-associated disorders may take days, weeks or even months to manifest, which is why it’s important for individuals who’ve been involved in an automobile accident to seek immediate medical attention. There are many different types of treatment options which can safely and effectively help treat whiplash. The purpose of the following article is to demonstrate the treatment guidelines of neck pain-associated disorders and whiplash-associated disorders.
Dr. Alex Jimenez’s Insight
Whiplash occurs when the sheer force of an impact causes the head and neck to jolt abruptly back-and-forth in any direction, stretching the complex structures surrounding the cervical spine beyond their normal range. Neck pain, headache and radiating pain resulting from whiplash are common complaints frequently reported by individuals after being involved in an automobile accident. However, whiplash can also result from a variety of other circumstances. Whiplash-associated disorders are a prevalent source of disability and a common reason many auto accident victims seek medical attention from chiropractors, physical therapists and primary care physicians. Fortunately, many treatment guidelines exist to safely and effectively improve as well as manage the symptoms of whiplash. Chiropractic care is a well-known alternative treatment option for whiplash-associated disorders. Spinal adjustments and manual manipulations can safely and effectively restore the original alignment of the spine, reducing symptoms and alleviating whiplash complications.
Neck pain and its associated disorders (NAD), including headache and radiating pain into the arm and upper back, are common and result in significant social, psychological, and economic burden.1-4 Neck pain, whether attributed to work, injury, or other activities,5 is a prevalent source of disability and a common reason for consulting primary health care providers, including chiropractors, physical therapists, and primary care physicians.6 The estimated annual incidence of neck pain measured in 4 studies ranged between 10.4% and 21.3%, with a higher incidence noted in office and computer workers.7 Although some studies report that between 33% and 65% of people have recovered from an episode of neck pain at 1 year, most cases follow an episodic course over a person’s lifetime, and thus, relapses are common.7 Neck pain is a leading cause of morbidity and chronic disability worldwide.5,8 In 2008 the Bone and Joint Decade Task Force on Neck Pain and Its Associated Disorders reported that 50% to 75% of individuals with neck pain also report pain 1 to 5 years later.4 Several modifiable and nonmodifiable environmental and personal factors influence the course of neck pain, including age, previous neck injury, high pain intensity, self-perceived poor general health, and fear avoidance.7
Neck pain related to whiplash-associated disorders (WADs) most commonly results from motor vehicle accidents.9,10 Whiplash-associated disorders disrupt the daily lives of adults around the world and are associated with considerable pain, suffering, disability, and costs.3,11 Whiplash-associated disorders are defined as an injury to the neck that occurs with sudden acceleration or deceler- ation of the head and neck relative to other parts of the body, typically occurring during motor vehicle collisions.10,12 The majority of adults with traffic injuries report pain in the neck and upper limb pain. Other common symptoms of WADs include headache, stiffness, shoulder and back pain, numbness, dizziness, sleeping difficulties, fatigue, and cognitive deficits.9,10 The global yearly incidence rate of emergency department visits as a result of acute whiplash injuries after road traffic crashes is between 235 and 300 per 100,000.3,13,14 In 2010, there were 3.9 million nonfatal traffic injuries in the United States.11 The economic costs of motor vehicle crashes that year totaled USD$242 billion, including $23.4 billion in medical costs and $77.4 billion in lost productivity (both market and household).11 In Ontario, traffic collisions are a leading cause of disability and health care use and expenditures, resulting in the automobile insurance system paying nearly CND$4.5 billion in accident benefits in 2010.15
More than 85% of patients experience neck pain after a motor vehicle accident, often associated with sprains and strains to the back and extremities, headache, psychological symptomatology, and mild traumatic brain injury.10 Whiplash injuries have an effect on general health, with recovery in the short term reported by 29% to 40% of individuals with WAD in Western countries that have compensation schemes for whiplash injuries. 16,17 The median time to first reported recovery is estimated at 101 days (95% confidence interval: 99-104) and about 23% are still not recovered after 1 year.13
The 2000-2010 Bone and Joint Decade Task Force on Neck Pain and its Associated Disorders recommended that all types of neck pain, including WADs,18 be included under the classification of NAD.19 NAD can be classified into 4 grades, distinguished by the severity of symptoms, signs, and impact on activities of daily life (Table 1).
The clinical management of musculoskeletal disorders, and neck pain in particular, can be complex and often involves combining multiple interventions (multimodal care) to address its symptoms and consequences.19 In this guideline, multimodal care refers to treatment involving at least 2 distinct therapeutic methods, provided by 1 or more health care disciplines.20 Manual therapy (including spinal manipulation), medication, and home exercise with advice are commonly used multimodal treatments for recent- onset and persistent neck pain.21,22 Thus, there is a need to determine which treatments or combinations of treatments are more effective for managing NAD and WAD.
The Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration20 recently updated the systematic reviews from the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders (Neck Pain Task Force).23 Consequently, it was deemed timely to update the recommendations of 2 chiropractic guidelines on NAD (2014)24 and WAD (2010)25 produced by the Canadian Chiropractic Association and the Canadian Federation of Chiropractic Regulatory and Educational Accrediting Boards (the “Federation”) into a single guideline.
The aim of this clinical practice guideline (CPG) was to synthesize and disseminate the best available evidence on the management of adults and elderly patients with recent onset (0-3 months) and persistent (N3 months) neck pain and its associated disorders, with the goal of improving clinical decision making and the delivery of care for patients with NAD and WAD grades I to III. Guidelines are “Statements that include recommendations intended to optimize patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options.”26
The target users of this guideline are chiropractors and other primary care health care providers delivering conservative care to patients with NADs and WADs, as well as policymakers. We define conservative care as treatment designed to avoid invasive medical therapeutic measures or operative procedures.
OPTIMa published a closely related guideline in the European Spine Journal.27 Although we reached similar results, OPTIMa developed recommendations using the modified Ontario Health Technology Advisory Committee (OHTAC) framework.28 In contrast, our guideline used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. GRADE provides a common, sensible, and transparent approach to grading quality (or certainty) of evidence and strength of recom- mendations (http://www.gradeworkinggroup.org). GRADE was the highest scoring instrument among 60 evidence grading systems29 and has been determined to be reproducible among trained raters.30 GRADE is now considered a standard in guideline development and has been adopted by many international guideline organizations and journals.31 The Canadian Chiropractic Guideline Initiative (CCGI) guideline panel considered available high-quality systematic reviews, updated the search of the peer-reviewed published reports up to December 2015, and then used the GRADE approach to formulate recommen- dations for the management of neck pain and associated disorders.
To inform its work, the CCGI considered recent advances in methods to conduct knowledge synthesis,32 derive evidence-based recommendations, 31,33 adapt high- quality guidelines, 34 and develop 35 and increase the uptake of CPGs.36,37 An overview of CCGI structure and methods is provided in Appendix 1.
Because no novel human participant intervention was required and secondary analyses were considered, the research presented in this guideline is exempt from institutional ethics review board approval.
The CCGI project lead (A.B.) appointed 2 co-chairs (J.O. and G.S.) for the guideline development group and nominated the project executive committee and the remaining guideline panelists. J.O. served as the lead methodologist on the guideline panel. G.S. helped ensure geographic representation of the panel and advised on specific duties of panel members, time commitment, and decision-making process for reaching consensus (develop- ment of key questions and of recommendations). To ensure a broad representation, the guideline panel included clinicians (P.D., J.W.), clinician researchers (F.A., M.D., C.H., S.P., I.P., J.S.) methodologists (J.O., A.B., M.S., J.H.), a professional leader/decision maker (G.S.), and 1 patient advocate (B.H.) to ensure that patient values and preferences were considered. One observer (J.R.) moni- tored the 3 face-to-face meetings of the guideline panel held in Toronto (June and September 2015 and April 2016).
All CCGI members, including guideline panelists and peer reviewers, were required to disclose any potential conflict of interest by topic before participation and during the guideline development process. There was no self- declaration of conflicts of interest among the panel or the reviewers.
Six topic areas (exercise, multimodal care, education, work disability, manual therapy, passive modalities) on the conservative management of NAD and WAD grades I to III were covered in 5 recent systematic reviews by the OPTIMa Collaboration,38-42 among a total of 40 reviews on the management of musculoskeletal disorders.20 The panel met over 2 days in June 2015 to brainstorm about potential key questions.
The panel assessed the quality of eligible systematic reviews using the AMSTAR tool43 and its 11 criteria (http://amstar.ca/Amstar_Checklist.php).
Because the last search dates of included systematic reviews were 2012,40,41 2013,38,39,42 and 2014,42 the panel updated the literature searches in Medline and Cochrane Central databases on December 24, 2015 using the published search strategies. We used a 2-phase screening process to select additional eligible studies. In phase 1, 2 independent reviewers screened titles and abstracts to determine the relevance and eligibility of studies. In phase 2, the same pairs of independent reviewers screened full-text articles to make a final determination of eligibility. Reviewers met to resolve disagreements and reach consensus on the eligibility of studies in both phases, with arbitration by a third reviewer if needed. Studies were included if they1 met the PICO (population, intervention, comparator, outcome) criteria and2 were randomized controlled trials (RCTs) with an inception cohort of at least 30 participants per treatment arm with the specified condition, because this sample size is considered the minimum needed for non-normal distributions to approx- imate the normal distribution.44
Data were extracted from the included studies identified in each systematic review, including study design, participants, intervention, control, outcomes, and funding.
The internal validity of included studies was assessed by the OPTIMa collaboration using the Scottish Intercollegiate Guidelines Network (SIGN) criteria.45
For articles retrieved from the updated search, pairs of independent reviewers critically appraised the internal validity of eligible studies using the SIGN criteria,46 similar to the OPTIMa collaboration reviews. Reviewers reached consensus through discussion. A third reviewer was used to resolve disagreements if consensus could not be reached. A quantitative score or a cutoff point to determine the internal validity of studies was not used. Instead, the SIGN criteria were used to assist reviewers in making an informed overall judgment on the risk of bias of included studies. 47
J.O. extracted data from scientifically admissible studies into evidence tables. A second reviewer (A.B.) indepen- dently checked the extracted data. We performed a qualitative synthesis of findings and stratified results based on the type and duration of the disorder (ie, recent [symptoms lasting b3 months] vs persistent [symptoms lasting N3 months]).
We used the Guideline Development Tool (http:// www.guidelinedevelopment.org), and assessed the quality of the body of evidence for our outcomes of interest by applying the GRADE approach.48 We used the evidence profiles to summarize the evidence.49 The quality of evidence rating (high, moderate, low, or very low) reflects our confidence in the estimate of the effect to support a recommendation and considers the strengths and limitations of the body of evidence stemming from risk of bias, imprecision, inconsistency, indirectness of results, and publication bias.50 Assessment of quality of evidence was carried out in the context of its relevance to the primary care setting.
Using the Evidence to Decisions (EtD) Framework (http://www.decide-collaboration.eu/etd-evidence- decision-framework), the panel formally met in September 2015 and April 2016 to consider the balance of desirable and undesirable consequences to determine the strength of each recommendation, using informed judgment on the quality of evidence and effect sizes, resource use, equity, acceptability, and feasibility. To make a recommendation, the panel needed to express an average judgment that was beyond neutral with respect to the balance between desirable and undesirable consequences of an intervention, as outlined in the EtD. We defined the strength rating of a recommendation (strong or weak) as the extent to which the desirable consequences of an intervention outweigh its undesirable consequences. A strong recommendation can be made when the desirable consequences clearly outweigh the undesirable consequences. In contrast, a weak recommendation is made when, on the balance of probabilities, the desirable consequences likely outweigh the undesirable consequences. 49,51
The panel provided recommendations based on the evidence if statistically and clinically significant differ- ences were found. The panel followed a 2-step process in making a recommendation. We first agreed that there should be evidence of clinically meaningful changes occurring over time in the study population and that a single consensus threshold of clinical effectiveness should be applied consistently. We reached a consensus decision that a 20% change in the outcome of interest within any study group was required to make a recommendation. The decision to use a 20% threshold was informed by current published reports and relevant available minimal clinically important differences (MCIDs).52-55
However, MCIDs can vary across populations, settings, and conditions and depending on whether within-group or between-group differences are being assessed. Therefore, the panel considered MCID values for the most relevant outcomes (ie, 10% for visual analog scale [VAS] or Neck Disability Index [NDI; 5/50 on the NDI], 20% for numerical rating scale [NRS]) and chose the more conservative of these values as the threshold when evaluating between group differences.52,54
Second, the results from relevant studies were used to formulate a recommendation where appropriate. A treat- ment determined to be effective (with statistically significant differences between baseline and follow-up scores and clinical significance based on the MCID applied in the study) was recommended by our panel. If a study found 2 or more treatments to be equally effective based on our threshold, then the panel recommended all equivalently effective treatments.
The EtD Frameworks were completed and recommen- dations were drafted over a series of conference calls with panel members after making judgments about 4 decision domains: quality of evidence (confidence in estimates of effect); balance of desirable (eg, reduced pain and disability) and undesirable outcomes (eg, adverse reactions); confidence about the values and preferences for the target population; and resource implications (costs).56,57 A synthe- sis of our judgments about the domains determined the direction (ie, for or against a management approach) and the strength of recommendations (the extent to which one can be confident that the desirable conse- quences of an intervention outweigh the undesirable consequences). A specific format was followed to formulate recommendations using patient description and the treatment comparator.56 Remarks were added for clarification if needed. If the desirable and undesirable consequences were judged to be evenly balanced and the evidence was not compelling, the panel decided not to write any recommendation.
A modified Delphi technique was used at an in-person meeting to achieve consensus on each recommendation.58 Using an online tool (www.polleverywhere.com), panelists voted their level of agreement with each recommendation (including quality of evidence and strength of recom- mendation) based on a 3-point scale (yes, no, neutral). Before voting, panelists were encouraged to discuss and provide feedback on each recommendation in terms of suggested wording edits or general remarks. To achieve consensus and be included in the final manuscript, each recommendation had to have at least 80% agreement with a response rate of at least 75% of eligible panel members. All recommendations achieved consensus in the first round.
A 10-member external committee composed of stake- holders, end-users, and researchers from Canada, the United States, and Lebanon (Appendix 2) independently reviewed the draft manuscript, recommendations, and supporting evidence. The AGREE II instrument was used to assess the methodological quality of the guideline.35 Feedback received was collected and considered in a revised draft for a second round of review. Chairs of the guideline panel provided a detailed response to reviewers’ comments. For a glossary of terms, please see Appendix 3.
Thirty-two standardized key questions were developed in line with the PICO (population, intervention, comparator, outcome) format. The panel recognized overlap in content and relevance among some key questions. After combining 3 questions, we ultimately addressed a total of 29 key questions (Table 2).
OPTIMa searches yield 26 335 articles screened.38-42 After removal of duplicates and screening, 26 273 articles did not meet selection criteria, leaving 109 articles eligible for critical appraisal. Fifty-nine studies (62 articles) published from 2007 to 2013 were deemed scientifically admissible and included in the synthesis (Appendix 4). Each review used was rated as either moderate or high quality (AMSTAR score 8-11).59
Our updated search yielded 7784 articles. We removed 1411 duplicates and screened 6373 articles for eligibility (Figs. 1-5). After screening, 6321 articles did not meet our selection criteria (phase 1), leaving 52 articles for full-text review (phase 2) and critical appraisal (studies on the topic of multimodal care (n = 12), structured patient education (n = 3), exercise (n = 8), work disability interventions (n = 13), manual therapy (n = 4), soft tissues (n = 2), and passive modalities (n = 6). Of the 52 RCTs, 4 scientifically admissible studies were included in our synthesis. The remaining articles failed to address the key question (n = 1); selected population (n = 2), outcomes (n = 13), or intervention (n = 11); had no between estimates (n = 19); or were duplicates (n = 1) or a secondary analysis of an included study (n = 1) (Appendix 5).
The GRADE evidence profile and risk of bias within included studies are presented in Tables 3-15 and Appendix 6, respectively.
We present recommendations as follows:
Key Question 1: Should neck manipulation vs neck mobilization be used for recent-onset (0-3 months) grades I to II NAD?
Summary of Evidence. One RCT by Leaver et al. 60 evaluated the effectiveness of neck manipulation or neck mobilization delivered by physiotherapists, chiropractors, or osteopaths for recent-onset grades I to II neck pain (≥2 NRS). All patients received advice, reassurance, or a continued exercise program as indicated for 4 treatments over 2 weeks unless recovery was achieved or a serious adverse event occurred. There was no statistically significant difference in Kaplan-Meier recovery curves between groups for recovery from neck pain and recovery of normal activity, and no statistically significant differences between groups for pain, disability, or other outcomes (function, global perceived effect, or health-related quality of life) at any follow-up point (Table 3).
One other RCT by Dunning et al.61 evaluated the effectiveness of a single high-velocity, low-amplitude (thrust) manipulation (n = 56) directed to the upper cervical spine (C1-C2) and upper thoracic spine (T1-T2) compared with a (nonthrust) mobilization (n = 51) directed to the same anatomical regions for 30 seconds for patients with neck pain. Findings indicated a greater reduction in pain (NPRS) and disability (NDI) in the thrust manipulation group compared with the mobilization at 48 hours. No serious adverse events were reported. Minor adverse events were not collected. This study did not inform our recommendation because1 patient complaints were not recent onset (mean duration N337 days in both groups), and2 outcomes were measured at 48 hours only. The Guideline Development Group (GDG) considered this an important study limitation because one cannot assume these benefits would have carried on for a longer period. The panel acknowledged, however, that some patients may value obtaining fast pain relief even if temporary.
The panel determined that the overall certainty in the evidence was low, with large desirable relative to undesirable effects. The relative small cost of providing the option would make it more acceptable to stakeholders and feasible to implement. Although the panel decided the desirable and undesirable consequences were closely balanced, the following statement was provided:
Recommendation: For patients with recent (0-3 months) grades I to II NAD, we suggest manipulation or mobilization based on patient preference. (Weak recommendation, low-quality evidence)
Key Question 2: Should integrated neuromuscular inhibition technique be used for recent-onset (0-3 months) grades I to II NAD?
Summary of Evidence. Nagrale et al.62 reported non– clinically significant differences for neck pain and disability outcomes at 4 weeks. This study suggested that a soft tissue therapy intervention to the upper trapezius, combining ischemic compression, strain-counterstrain, and muscle energy technique, provides similar clinical benefit compared with muscle energy technique alone. Participants were required to have neck pain of less than 3 months’ duration.
The panel determined moderate certainty in the evidence, with small desirable and undesirable effects and no serious adverse events. Low costs are required for the intervention and no specific equipment is needed, with the exception of training to provide the technique. Because the intervention is widely practiced and taught, it is acceptable and feasible to implement. However, its effects on health equities cannot be determined. Overall, the panel decided the balance between the desirable and undesirable consequences was uncertain, and more evidence is needed before a recommendation can be made.
Key Question 3: Should multimodal care vs intramuscular ketorolac be used for recent (0-3 months) grades I to III NAD?
Summary of Evidence. McReynolds et al. 63 presented short-term outcomes of pain intensity and concluded that sessions of multimodal care (manipulation, soft tissue techniques) provided equivalent outcomes to an intramuscular injection of ketorolac. However, the follow-up time of 1 hour is generally atypical and the dosing was determined to be incomplete for multimodal care as reported. Furthermore, the study was limited to an emergency setting only.
The panel determined low certainty in the clinical evidence, with small desirable and undesirable effects. There is relatively low risk for multimodal care, considering the reported outcomes were equal. From a clinician standpoint, resources required are small assuming no additional staff are needed. However, one practitioner gave most multimodal therapies. Expenses may vary depending on the definition of multimodal care. This option should not create health inequities, except for those who cannot access clinicians or choose to pay out of pocket, and would be feasible to implement. Professional associ- ations would generally support the option, yet extended multimodal therapies can incur additional costs, which can be unfavorable to both payors and patients. Overall, the balance between the desirable and undesirable conse- quences is uncertain and more research is needed in this area before any recommendation can be made.
Key Question 4: Should multimodal care vs home exercises vs medication be used for recent-onset (0-3 months) grades I to II NAD?
Summary of Evidence. One RCT by Bronfort et al.22 evaluated the efficacy of multimodal care over 12 weeks compared with a 12-week home exercise and advice program or medication on neck pain (11-box NRS) and disability (NDI) in 181 adult patients with acute and subacute neck pain (2-12 weeks’ duration and a score of ≥3 on a 10-point scale). Multimodal care by a chiropractor (mean of 15.3 visits, range 2-23) included manipulation and mobilization, soft tissue massage, assisted stretching, hot and cold packs, and advice to stay active or modify activity as needed. Daily home exercise was to be done up to 6 to 8 times per day (individualized program including self- mobilization exercise of the neck and shoulder joints) with advice by a physical therapist (two 1-hour sessions, 1-2 weeks apart on posture and activity of daily living). Medication prescribed by a physician included nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, opioid analgesic, or muscle relaxants (dosage was not reported). The results displayed in Table 4 indicated that multimodal care and home exercises and advice were as effective as medication in reducing pain and disability at short term (26 weeks). However, medication was associated with a higher risk for adverse events (mostly gastrointestinal symptoms and drowsiness in 60% of participants) than home exercises. The choice of medications was based on the participant’s history and response to treatment. Clinicians and patients should be aware that current evidence is insufficient to determine the effectiveness of long-term opioid therapy for improving chronic pain and function. Importantly, evidence supports a dose-dependent risk for serious harms, including increased risk for overdose, dependence, and myocardial infarction.64
Recommendation: For patients with recent (0-3 months) neck pain grades I to II, we suggest either range-of-motion home exercises, medication, or multimodal manual therapy for reduction in pain and disability. (Weak recommendation, moderate- quality evidence)
Remark: Home exercises included education self-care advice, exercises, and instruction on activities of daily living. Medication included NSAIDs, acetaminophen, muscle relaxant, or a combination of these. Multimodal manual therapy included manipulation and mobilization with limited light soft tissue massage, assisted stretching, hot and cold packs, and advice to stay active or modify activity as needed.
Key Question 5: Should supervised graded strengthening exercises vs advice be used for recent-onset (0-3 months) grade III NAD?
Summary of Evidence. One RCT by Kuijper et al.65 evaluated the effectiveness of supervised strengthening exercises compared with advice to stay active for recent-onset grade III neck pain. This RCT reported that strengthening exercises (n = 70) were more effective than advice to stay active (n = 66).65 Trial participants were followed at 3 weeks, 6 weeks, and 6 months. Based on panel consensus, outcomes determined to be important in the assessment of effectiveness in this RCT included neck and arm pain (VAS) and disability (NDI). These outcomes were both statistically and clinically significant (Table 5).
In this RCT, the strengthening exercise program was delivered by physiotherapists 2 times per week for 6 weeks.65 It included supervised graded strengthening exercises for the shoulder and daily home exercises to strengthen the superficial and deep neck muscles (mobility, stability, and muscle strengthening). Participants in the comparison group were advised to continue daily activities. Both groups were allowed to use painkillers. See Key Question 6 for a recommendation on cervical collar.
Recommendation: For patients with recent (0-3 months) grade III neck and arm pain, we suggest supervised graded strengthening exercises* rather than advice alone.† (Weak recommendation, moderate-quality evidence)
Remark: *Supervised graded strengthening exercises con- sisted of strengthening and stability exercises twice a week for 6 weeks with daily home exercises (which included mobility, stability, and muscle strengthening). †Advice alone consisted of maintaining activity of daily living without specific treatment.
Key Question 6: Should cervical collar vs graded strengthening exercise program be used for recent-onset (0-3 months) grade III NAD?
Summary of Evidence. One RCT by Kuijper et al.65 randomly assigned 205 patients with recent-onset neck cervical radiculopathy (NAD grade III) to 1 of 3 groups 1 : Rest and semi-hard cervical collar for 3 weeks, then weaned off during weeks 3-6 2 ; physiotherapy (mobilizing and stabilizing the cervical spine, standardized graded neck strengthening exercises twice per week for 6 weeks, and education to do daily home exercises); or3 a control group (wait and see with advice to continue daily activities). All patients received written and oral reassurance about the usually benign course of the symptoms and were allowed painkillers.
Wearing a semi-hard cervical collar or receiving standardized graded strengthening exercise program and home exercises for 6 weeks provided similar improvements in arm pain (VAS), neck pain (VAS), or disability (NDI) compared with a wait-and-see policy at 6 weeks. There were no between-group differences at 6 months.
Because of uncertainty about potential for iatrogenic disability associated with the prolonged use of cervical collar,27,42 one recommendation made in the current guideline favoring strengthening exercise programs over advice, and the lack of consensus among the guideline panel, the GDG decided not to make a recommendation against the use of cervical collar (first vote on the proposed recommendation with direct results from the study [11% agree, 11% neutral, 78% disagree, 1 abstained]). A second vote favored also removing the remark from the recommendation (27% agree, 9% neutral, 64% disagree, 1 did not vote). Choice should be based on patient’s preference and management changed if recovery is slow.66
Key Question 7: Should low-level laser therapy be used for recent-onset (0-3 months) grade III NAD?
Summary of Evidence. One RCT by Konstantinovic et al.67 evaluated the effectiveness of low-level laser therapy (LLLT) delivered 5 times per week for 3 weeks compared with placebo (inactive laser treatment) for recent-onset grade III neck pain. LLLT leads to statistically but not clinically significant improvements in neck pain and disability at 3 weeks compared with placebo. Transitional worsening in pain (20%) and persistent nausea (3.33%) were observed in the LLLT group, whereas no adverse events were reported in the placebo group.
The panel determined the overall certainty of the evidence was moderate, with small desirable effects and minor adverse events. LLLT can be expensive. If practitioners choose not to purchase, it may negatively affect health equities. However, the option is acceptable to stakeholders and is relatively easy to implement. The panel was uncertain about the balance between desirable and undesirable consequences and voted against making a recommendation because of a lack of clear evidence (LLLT was no better than placebo but both groups demonstrated within-group change over time).
Key Questions 8 and 9: Should work disability prevention interventions vs fitness and strengthening exercise program be used for recent-onset nonspecific work-related upper limb disorders? Should work disability prevention interventions be used for recent-onset work-related neck and upper limb complaints?
In reviewing the evidence on work disability prevention interventions,41 the GDG concluded that the balance between desirable and undesirable consequences was “closely balanced or uncertain.” As a result, the guideline panel was unable to formulate recommendations for these key questions, yet future research is very likely to either positively or negatively support the various types of work disability prevention interventions.
Although some benefits were reported favoring computer-prompted and instructed exercise interventions,68 the incremental self-reported improvement was insufficient to formulate a recommendation considering1 a follow-up period of 8 weeks in reviewed studies is too short to estimate long-term sustained benefits; and2 the potential costs related to programming and worker instruction may be significant.
Overall, it appears that adding computer-prompted exercises (with workplace breaks), or workplace breaks alone, to a program of ergonomic modification and education improves self-perceived recovery and symptomatic benefits in computer workers with neck and upper back complaints.41 However, it is unclear whether the addition of computer- prompted exercises to the various established workplace interventions alters perceived or objective health outcomes. Future research may identify added benefits in order for stakeholders to consider the extra cost as being surmountable.
Key Question 10: Should multimodal care vs education be used for recent (0-3 months) grades I to III WAD?
Summary of Evidence. A 2-part RCT by Lamb et al.69 evaluated the effectiveness of oral advice compared with written material for improving pain (self-rated neck pain) and disability (NDI) in patients with recent-onset grades I to III WAD. Lamb et al.69 included a total of 3851 participants with a history of WAD grades I to III of less than 6 weeks’ duration who sought treatment at an emergency department. A total of 2253 participants received active management advice in the emergency department incorporating oral advice and the Whiplash Book, which included reassurance, exercises, encouragement to return to normal activities, and advice against using a collar; 1598 participants received usual care advice, including verbal and written advice along with anti-inflammatory medication, physiotherapy, and analgesics. No between-group difference was observed in self-rated neck pain and disability at 12-month follow-up and no difference in workdays lost was observed at 4-month follow-up (Table 6).
Lamb et al.69 included 599 participants with WAD grades I to III that persisted for 3 weeks after attending emergency departments. Three hundred participants were treated by a physiotherapist (maximum 6 sessions over 8 weeks) including psychological strategies (goal setting or pacing, coping, reassurance, relaxation, pain and recov- ery), self-management advice (posture and positioning), exercises (shoulder complex mobilization and range of motion [ROM]; cervical and scapular stability and proprioception), and cervical and thoracic spine Maitland mobilization and manipulation; a total of 299 received single-session reinforcement advice from a physiothera- pist during their previous visit to emergency department. No difference in self-rated disability was identified at 4-month follow-up; however, greater reductions in workdays lost after 8-month follow-up were determined with self-management advice over single-session rein- forcement. Similar findings were found in an earlier study.70
Recommendation: For adult patients with recent (0-3 months) WAD grades I to III, we suggest multimodal care over education alone. (Weak recommendation, moderate-quality evidence)
Remark: Multimodal care may consist of manual therapy (joint mobilization, other soft tissue techniques), education, and exercises.
Key Question 11: Should structured patient education vs education reinforcement be used for recent-onset (0-3 months) WAD?
Summary of Evidence. Lamb et al.69 reported outcomes at 4 months for self-rated disability, identifying no clinically significant differences between groups. The study sug- gested that oral advice and an educational pamphlet provide similar benefits.
The panel determined moderate quality in the clinical evidence, yet uncertain desirable effects with small, minor, and transient adverse events. Relatively few resources would be required for the intervention, and wide dissemination of educational materials through electronic tools can help reduce inequities. The option is acceptable to stakeholders and feasible to implement. Overall, the desirable consequences probably outweigh the undesirable consequences. The panel determined this topic and its evidence has substantial overlap with Key Question 10. Therefore, one recommendation was made, addressing both topics.
Key Question 12: Should supervised exercise (ie, qigong exercise) vs no treatment (wait listing) be used for persistent (N3 months) grades I to II NAD?
Summary of Evidence. Two RCTs (Table 7) evaluated the effectiveness of supervised qigong compared with super- vised exercise therapy and no treatment on neck pain (101-point VAS), disability (NDI), and Neck Pain and Disability Scale in a total of 240 patients with chronic neck pain (N6 months). 71,72 Rendant et al. 72 reported that, in adults with chronic neck pain, supervised qigong is more effective than no treatment and as effective as exercise therapy in reducing neck pain and disability at 3 and 6 months. Conclusions regarding the effectiveness of these 2 interventions compared with no treatment in patients aged older than 55 years cannot be drawn from the included studies.
In their study of these interventions for neck pain in elderly patients, von Trott et al.71 observed a reduction in pain and disability in both intervention groups at 3 and 6 months (although not statistically significant). The quality of the evidence was downgraded to low based on the SIGN criteria (concealment method not reported). In the von Trott et al. study, the interventions consisted of two 45-minute sessions per week for 3 months (a total of 24 sessions),71 whereas in the Rendant et al. study, interventions consisted of 12 treatments in the first 3 months and 6 treatments in the following 3 months (total of 18 sessions).72 Exercise therapy in both studies included repeated active cervical rotations and strengthening and flexibility exercises in the form of Dantian qigong71 or Neiyanggong qigong.72 Similar minor transient side effects were reported in both the intervention and comparison groups.
Recommendation: For adult patients with persistent (N6 months) neck pain grades I to II, we suggest supervised group exercises* to reduce neck pain and disability. (Weak recommendation, moderate-quality evidence)
Remark: Patients received 18 to 24 group sessions during a period of 4 to 6 months. Patients considered had a rating of 40/100 on a pain scale (VAS). The intervention group reached suggested MCID level of 10% difference for pain and functional outcomes. *Exercises included qigong or ROM, flexibility, and strengthening exercises. No evidence of significant effect in the elderly population.
Key Question 13: Should supervised yoga vs education be used for persistent (N3 months) grades I to II NAD?
Summary of Evidence. Yoga is an ancient Indian practice involving postural exercises, breathing control, and med-
itation. 20 One RCT by Michalsen et al. 73 evaluated the effectiveness of Iyengar yoga compared with a self-care/exercise program on neck pain (VAS) and disability (NDI) in 76 patients with chronic neck pain (pain for at least 3 months and a score of more than 40 mm on a 100-mm VAS). Yoga consisted of a weekly 90-minute session for 9 weeks of a wide range of postures aimed to enhance flexibility, alignment, stability, and mobility. The self-care/ exercise group had to practice for 10 to 15 minutes at least 3 times a week a series of 12 exercises focusing on muscle stretching and strengthening and joint mobility. The results indicated that yoga is more effective for reducing neck pain and disability at short term (4 and 10 weeks) than self-care/ exercise (Table 8). No serious adverse events were reported in either group. In this study, the quality of evidence was downgraded to low because blinding was “poorly ad- dressed.”45
One RCT by Jeitler et al.74 evaluated the effectiveness of Jyoti meditation compared with exercise on neck pain (VAS). The results showed that Jyoti meditation (sitting motionless, repeating a mantra, and visual concentration while keeping the eyes closed) is more effective than exercise (established and previously used self-care manual for specific exercise and education for chronic neck pain).74 Because Jyoti meditation only includes 1 of the 3 components of yoga (ie, meditation), Jeitler et al.74 was not considered in developing the following recommendation.
Recommendation: For patients with persistent (N3 months) grades I to II neck pain and disability, we suggest supervised yoga over education and home exercises for short- term improvement in neck pain and disability. (Weak recommendation, low-quality evidence)
Remark: Baseline intensity of pain was more than 40/100 and duration was at least 3 months. Yoga was specific to the Iyengar type, with a maximum of 9 sessions over 9 weeks.
Key Question 14: Should supervised strengthening exercises vs home ROM or stretching exercises be used for persistent (N3 months) grades I to II NAD?
Summary of Evidence. Three RCTs evaluated the effectiveness of supervised strengthening exercises compared with home exercises for grades I to II neck pain and disability.38 Two RCTs (Hakkinen et al.75 and Salo et al.76) reported no significant between group differences at 1 year for primary or secondary outcomes. One RCT (N = 170) reported that supervised strengthening exercises were more effective than home ROM exercises.77 Two smaller RCTs (N = 107) found that both treatments are equally effective.75,76 All 3 trials had a follow-up of 1 year. Based on our panel’s consensus, outcomes determined to be important in the assessment of effectiveness for these RCTs included pain (NRS) and disability (NDI).
In the RCT by Evans et al.77 the strengthening exercise program (delivered by exercise therapists) was determined to be more effective than home exercises. The program included 20 supervised sessions over a period of 12 weeks and consisted of neck and upper body dynamic resistance strengthening program with and without spinal manipula- tive therapy.77 Conversely, the home exercises included an individualized program of neck and shoulder self- mobilization with initial advice regarding posture and daily activities (Table 9). In the 2 RCTs demonstrating equivalence, the strengthening program included 10 supervised sessions over 6 weeks of isometric exercises for the neck flexors and extensors, dynamic shoulder and upper extremity exercises, abdominal and back exercises, and squats.43,44
A fourth RCT by Maiers et al.78 assessed the effectiveness of supervised rehabilitative exercises in combination with and compared with home exercises alone for persistent neck pain in individuals aged 65 years or older. All participants in the study received 12 weeks of care. One group received 20 supervised 1-hour exercise sessions in addition to home exercises. Home exercises consisted of four 45- to 60-minute sessions to improve flexibility, balance, and coordination and enhance trunk strength and endurance. Participants also received instruc- tions on pain management, practical demonstrations of body mechanics (lifting, pushing, pulling, and rising from a lying position), and massaging to stay active. Results favored supervised rehabilitative exercises combined with home exercises over home exercise for pain (NRS) and disability (NDI) at 12 weeks. However, between-group differences did not reach statistical significance.
Recommendation: For patients with persistent (N3 months) grades I to II neck pain, we suggest supervised strengthening exercises or home exercises. (Weak recommendation, low-quality evidence)
Remark: For reduction in pain, supervised strength- ening exercises, provided along with ROM exercises and advice, were evaluated at 12 weeks within 20 sessions. Home exercises include stretching or self-mobilization.
Key Question 15: Should strengthening exercises vs general strengthening exercises be used for persistent (N3 months) grades I to II NAD?
Summary of Evidence. Griffiths et al.79 presented non– clinically significant outcomes for neck pain and disability among patients with persistent neck pain and concluded there is no added benefit of incorporating specific isometric exercise to a general exercise program. Dosages were up to 4 sessions per 6-week period, with advice for 5 to 10 times at home. The general exercise program consisted of postural exercise, active ROM, 5 to 10 times daily with reinforcement.
The panel determined there is low certainty in the clinical evidence and uncertainty in the desirable effects of the intervention. Isometric exercises have little anticipated adverse effects, require minimal resources, and are generally acceptable to stakeholders and feasible to implement. Yet uncertainty remains regarding their effects on health equity and the overall balance between desirable and undesirable consequences. More research is needed in this area before a recommendation can be made.
Key Question 16: Should combined supervised strengthening, ROM, and flexibility exercises vs no treatment (wait listing) be used for persistent (N3 months) grades I to II NAD?
Summary of Evidence. von Trott et al. 71 and Rendant et al. 72 presented significant outcomes for reduction in neck pain and disability that favor combined strengthening, ROM, and flexibility exercises. Both studies address different popula- tions and lead to similar outcomes (von Trott et al.71 addressed elderly populations).
The panel determined there was moderate certainty in the clinical evidence, with large desirable and small undesirable anticipated effects. Yet there may be differences in adverse events for strengthening vs ROM and flexibility exercises, along with the chal- lenges of such adverse events being self-reported. For example, strengthening exercises likely coincide with short-term pain after the intervention. Further, signifi- cant space may be required for exercises, which may incur large costs that need to be considered up front. As a result, there is uncertainty about the feasibility to implement and whether this could widely affect health inequalities. However, the option would be acceptable to stakeholders. Overall, the desirable consequences would probably outweigh the undesirable consequences. The panel determined this topic and its evidence has substantial overlap with Key Question 12 (qigong was considered exercise). Therefore, 1 recommendation was made, addressing both topics.
Key Question 17: Should multimodal care vs self-management be used for persistent (N3 months) grades I-II NAD?
Summary of Evidence. One RCT by Gustavsson et al.80 evaluated the effectiveness of self-management of persis- tent musculoskeletal tension type neck pain for grades I to II neck pain. They compared treatment effects of a multicom- ponent pain and stress self-management group intervention (n = 77) to individually administered multimodal physical therapy (n = 79). Measures of pain (NRS) and disability (NDI) were collected at baseline and at 10 and 20 weeks. Both groups had within-group differences for decreased pain intensity and disability. At the 20-week follow-up after an average of 7 sessions, based on the measures used, the multicomponent pain and stress self-management group intervention had a greater treatment effect on coping with pain and patients’ self-reported pain control and disability than the multimodal care group. The initial treatment effects were largely maintained over a 2-year follow-up period (Table 10).81
Recommendation: For patients with persistent (N3 months) neck pain and associated disorders grades I to II, we suggest multimodal care* or stress self-management† based on patient preference, prior response to care, and resources available. (Weak recommendation, low-quality evidence)
Remark: *Individualized multimodal care may include manual therapy (manipulation, mobilization, massage, trac- tion), acupuncture, heat, transcutaneous electrical nerve stimulation, exercise, and/or ultrasound. †Stress self-manage- ment may include relaxation, balance and body awareness exercises, pain and stress self-management lectures, and discussion. The multimodal care group received an average of 7 (range 4-8) sessions, compared with 11 (range 1-52) sessions for the stress self-management group over 20 weeks.
Key Question 18: Should structured patient education vs massage therapy be used for persistent (N3 months) NAD?
Summary of Evidence. Sherman et al.82 reported non– clinically significant outcomes at 4 weeks for disability. This study suggests a mailed self-care book and a course in massage therapy provide similar clinical benefits for
patients with persistent neck pain.
The panel determined the overall certainty of the evidence was low, with relatively large anticipated effects and no serious adverse events noted from intervention (some headaches possibly). There is uncertainty in the costs required, including necessary staff, equipment, and mate- rials. Yet this option is feasible to implement in most settings and has strong implications for reducing health inequities. As a preventive strategy, the intervention is acceptable to stakeholders, including the chiropractic practitioners, patients, and policymakers. The panel was uncertain about the balance between the desirable and undesirable consequences. Additional high-quality studies are needed in this area before any recommendation can be made.
Key Question 19: Should manipulation be used for persistent grades I to II NAD?
Summary of Evidence. Evans et al.77 compared spinal manipulation in addition to 20 weeks of supervised exercise therapy (20 sessions) to supervised exercise therapy alone in adults with persistent grades I to II neck pain, whereas Maiers et al.78 compared spinal manipulation in addition to home exercises (20 sessions maximum) to home exercise alone in seniors with persistent grades I to II neck pain. Pain and disability outcomes at 12 and 52 weeks did not reach statistical significance in between-group differences, except for pain level at 12 weeks in the Maiers study.78 A third RCT by Lin et al.83 allocated 63 persistent neck pain patients (NAD I-II) to the experimental group (n = 33) treated with cervical spine manipulation and traditional Chinese massage (TCM) compared with TCM alone (n = 30) over 3 weeks. Results favored cervical manipulation with TCM over TCM alone for pain (NPS) and disability (Northwick Park Neck Disability Questionnaire) at 3 months (Table 11).
The panel concluded low certainty in the evidence, with small desirable and undesirable effects of the intervention. Few resources are required for the intervention, and it is probably acceptable to stakeholders and feasible to implement. Although the panel decided the desirable and undesirable consequences were closely balanced, the following statement was provided.
Recommendation: For patients with persistent grades I to II NAD, we suggest manipulation in conjunction with soft tissue therapy. (Weak recommendation, low-quality evidence)
Remark: Evaluated after eight 20-minute sessions (over a 3-week period). Does not include manipulation as a standalone treatment.
Key Question 20: Should massage vs no treatment (wait listing) be used for persistent (N3 months) grades I to II NAD?
Summary of Evidence. Sherman et al.82 and Lauche et al.84 reported non–clinically significant differences in outcomes for disability at 4 and 12 weeks, respectively. Sherman et al.82 suggested Swedish and/or clinical massage with verbal self- care advice provides similar clinical benefit to a self-care book for disability outcomes. Lauche et al.84 suggested cupping massage and progressive muscle relaxation lead to similar changes in disability. Sherman et al.85 reported outcomes for neck pain and disability at 4 weeks and suggested that higher doses of massage provide superior clinical benefit (Table 12).
The panel determined low certainty in the evidence, with small desirable and undesirable effects. Additional costs may be needed to get clinical benefit. Sherman et al.85 suggested a minimum of 14 hours of staff time needed. Because of the costs associated with high-dose massage, it may not be entirely acceptable to patients or payors. However, this option is feasible and relatively easy to implement in educated and affluent populations similar to subjects primarily studied.85 Overall, the panel decided the desired consequences probably outweigh the undesirable consequences and suggest offering this option.
Recommendation: For patients with persistent (N3 months) grades I to II NAD, we suggest high-dose massage over no treatment (wait listing) based on patient preferences and resources available. (Weak recommendation, low-quality evidence)
Remark: Interventions were given 3 times for 60 minutes a week for 4 weeks. Lower dosages and duration did not have therapeutic benefit, and we cannot suggest offering as an option.
Key Question 21: Should LLLT be used for persistent (N3 months) grades I to II NAD?
Summary of Evidence. After full-text screening and review, no studies addressing between-group differences among outcomes of pain or disability were included to inform this key question. The lack of evidence and uncertainty in the overall balance between desirable and undesirable consequences led the panel to decide not to write a recommendation for this topic at this time. More high-quality studies are needed in this area before certainty in judgments or recommendations can be made.
Key Question 22: Should transcutaneous electrical nerve stimulation vs multimodal soft tissue therapy program be used for persistent (N3 months) grades I to II NAD?
Summary of Evidence. After full-text screening and review, no studies addressing between-group differences among outcomes of pain or disability were included to inform this key question. The lack of evidence and uncertainty in the overall balance between desirable and undesirable consequences led the panel to decide not to write a recommendation for this topic at this time. More high quality studies are needed in this area before certainty in judgments or recommendations can be made.
Key Question 23: Should cervical traction be used for grade III NAD (variable duration)?
Summary of Evidence. After full-text screening and review, no studies addressing between-group differences among outcomes of pain or disability were included to inform this key question. The lack of evidence and uncertainty in the overall balance between desirable and undesirable consequences led the panel to decide not to write a recommendation for this topic at this time. More high-quality studies are needed in this area before certainty in judgments or recommendations can be made.
Key Question 24: Should multimodal care vs continued practitioner care be used for persistent grades I to III NAD?
Summary of Evidence. One RCT by Walker et al.86 evaluated the effectiveness of multimodal care for neck pain with or without unilateral upper extremity symptoms (grades I-III). They compared treatment effects of combined multimodal care and home exercises (n = 47) to multimodal minimal intervention (n = 47). Both intervention groups received on average of 2 sessions per week for 3 weeks. No interventions were rendered after 6 weeks. Baseline self- reported questionnaires included neck and arm pain (VAS) and disability (NDI). All measures were repeated at 3, 6, and 52 weeks. Patients in the multimodal care and home exercise group had significantly greater reduction in short-term neck pain and in short-term and long-term disability compared with the multimodal minimal interven- tion group (Table 13). A secondary analysis of the Walker et al. study87 determined that patients receiving both cervical thrust and nonthrust manipulations did no better than the group receiving cervical nonthrust manipulations only. This underpowered secondary analysis prohibits any definitive statement regarding the presence or absence of a treatment advantage of one approach over the other. The reduction in pain reported by Walker’s multimodal care and exercise group compared favorably to the change scores reported by other studies, including Hoving et al.88,89
In an RCT, Monticone et al.90 evaluated the effective- ness of multimodal care for persistent neck pain. They compared treatment effect of multimodal care alone (n = 40) to multimodal care in conjunction with cognitive behavioral treatment (n = 40). Both groups had a reduction in pain (NRS) and disability (NPDS), but there were no clinically significant differences between the groups at 52 weeks. The addition of a cognitive behavioral treatment did not provide greater outcomes than multimodal care alone.
Recommendation: For patients presenting with persistent neck pain grades I to III, we suggest clinicians offer multimodal care* and/ or practitioner advice based on patient preference. (Weak recommendation, low-quality evidence)
Remark: *Multimodal care and exercises may consist of thrust/nonthrust joint manipulation, muscle energy, stretching, and home exercises (cervical retraction, deep neck flexor strengthening, cervical rotation ROM). †Multimodal minimal intervention may consist of postural advice, encouragement to maintain neck motion and daily activities, cervical rotation ROM exercise, instructions to continue prescribed medication, and therapeutic pulsed (10%) ultrasound at 0.1 W/cm2 for 10 minutes applied to the neck and cervical ROM exercises.
Key Question 25: Should group exercises vs education or advice be used for workers with persistent neck and shoulder pain?
Summary of Evidence. We have combined the key questions for “Should structured patient education vs exercise programs be used for persistent neck pain and associated disorders in workers?” and “Should workplace-based exercises vs advice be used for neck pain in workers?” One large cluster RCT (n = 537) by Zebis et al.91 evaluated the effectiveness of strength training in the workplace compared with receiving advice to stay physically active on nonspecific neck and shoulder pain intensity. The findings indicated a similar reduction in neck and shoulder pain intensity at 20 weeks for the exercise program compared with advice (Table 14). The intervention consisted of 3 sessions per week, each lasting 20 minutes, for up to 20 weeks (total of 60 sessions).
The workplace exercise program consisted of high- intensity strength training relying on principles of progres- sive overload and involved local neck and shoulder muscles strengthening with 4 different dumbbell exercises and 1 exercise for the wrist extensor muscles. More than 15% of workers assigned to the workplace exercise group reported minor and transient complaints. The comparison group reported no adverse events.
A subgroup analysis92 of the primary Zebis et al. study91 included 131 women with a baseline neck pain rating of at least 30 mm VAS from the 537 male and female participants. Results favored specific resistance training over advice to stay active for pain (VAS) at 4 weeks. This study was not included because findings were already considered in the primary study.
Recommendation: For workers with persistent neck and shoulder pain, we suggest mixed supervised and unsupervised high- intensity strength training or advice alone. (Weak recommendation, moderate-quality evidence)
Remark: For reduction in pain intensity, 3 sessions per week, each lasting 20 minutes, over a 20-week period. Exercise includes strengthening. Extra resources are likely required for complete exercise intervention implementation.
Key Question 26: Should structured patient education vs exercise programs be used for persistent (N3 months) NAD in workers?
Summary of Evidence. Andersen et al.93 reported non– clinically significant outcomes at 10 weeks for neck and shoulder pain, suggesting weekly e-mailed information on general health behaviors and shoulder abduction exercise programs provide similar clinical benefit. Yet implementa- tion of high-intensity strength training exercises in industrial workplaces (implementation of exercise into day-to-day life and to increase active leisure time) is generally supported.94,95 In another RCT, pain reduction was significantly greater than in the group receiving advice alone. 91 Findings from Zebis et al. 91 are also included in the exercise intervention section of this guideline.
The panel determined moderate certainty in the clinical evidence, with small desirable and undesirable effects of the intervention. The resources required are relatively small, assuming the practitioner presents the education to the patient. Health inequities would be positively affected, and the intervention would be acceptable to stakeholders and feasible to implement. The panel decided not to repeat these findings in the current section. The panel felt that the benefits of increasing the frequency and intensity of exercise regimes was not restricted to those working in an industrial environment or to any specific population subgroup with the exception of older adults.
Key Questions 27-29: Should work-based hardening vs clinic-based hardening be used for persistent (N3 months) work-related rotator cuff tendinitis? Should work disability prevention interventions be used for persistent neck and shoulder pain? Should work disability prevention interventions be used for persistent (N3 months) upper extremity symptoms?
Summary of Evidence. In reviewing the evidence on work disability prevention interventions,41 the GDG concluded that the balance between desirable and undesirable consequences was “closely balanced or uncertain” for Key Questions 27-29. As a result, the guideline panel was unable to formulate recommendations for these key questions, yet future research is very likely to either positively or negatively support the various types of work disability prevention interventions.
Key Question 30: Should supervised general exercise and advice vs advice alone be used for persistent (N3 months) grades I to II WAD?
Summary of Evidence. In an RCT, Stewart et al. (2007)96 evaluated the effectiveness of 3 advice sessions alone compared with 3 advice sessions combined with 12 exercise sessions over 6 weeks on neck pain (NRS) and disability (NDI) among 134 patients with persistent grades I to II WAD. The results, presented in Table 15, indicated that supervised exercises with advice are as effective as advice alone at long term (12 months). Advice included standardized education, reassurance, and encouragement to resume light activity and consisted of 1 consultation and 2 follow-up phone contacts. However, the quality of the evidence was downgraded to low based on SIGN criteria (randomization and outcome measurement were “poorly addressed”) and the low number of participants and events.45
A pragmatic trial assigned 172 patients with persistent WAD grades I to II to receive a comprehensive 12-week exercise program (20 sessions including manual therapy technique the first week [no manipulation] and cognitive behavioral therapy delivered by physiotherapists) or advice (1 session and telephone support).97 The comprehensive exercise program was not more effective than advice alone for pain reduction or disability, although findings favored a comprehensive physiotherapy exercise program over advice.
The panel determined low certainty in the evidence, with small desirable and undesirable effects and no serious adverse events (5 patients who received the comprehensive exercise program and 4 who received advice had minor transient adverse events). Overall, the panel decided the balance between the desirable and undesirable conse- quences such as costs was uncertain, and more evidence is needed before a recommendation can be made.
In a 20-week cluster RCT, Gram et al. (2014)98 randomly assigned 351 office workers to 2 training groups receiving the same total amount of planned exercises 3 times per week, with 1 group supervised throughout the intervention period and the other receiving minimal supervision only initially, and a reference group (without exercise). Although results indicated that supervised training at the workplace reduced neck pain, results were not clinically significant and both training groups improved independently of the extent of supervision. The panel decided not to consider this study in formulating a recommendation because exercise was not directly com- pared with advice and an important loss to follow-up occurred across groups. Although supervised exercise appears to be beneficial, costs can be high. This could possibly be mitigated, however, by offering group treat- ment, which may increase compliance and accountability with a supervised group.
Recommendation: For patients with persistent (N3 months) grades I to II WAD, we suggest supervised exercises with advice or advice alone based on patient preference and resources available. (Weak recommendation, low-quality evidence)
Remark: Extra resources may be required for supervised exercises.
Key Question 31: Should multimodal care vs self- management program be used for persistent (N3 months) grade II WAD?
Summary of Evidence. Jull et al.99 reported no clinically or statistically significant outcomes for pain and disability at 10 weeks. They suggested that multimodal care (exercises, mobilization, education, and ergonomic advice) provided similar outcomes to a self-management program based on an educational booklet (mechanism of whiplash, reassur- ance of recovery, stay active, ergonomic advice, exercise). Care did not include high-velocity manipulation. Although this study is specific to physiotherapists, it is well within the scope of chiropractors (manual therapists).
One other RCT by Jull et al.100 evaluated the effectiveness of multidisciplinary individualized treat- ments for patients with acute whiplash (b4 weeks postinjury). Patients randomly assigned to pragmatic intervention (n = 49) could receive medication including opioid analgesia, multimodal physiotherapy, and psy- chology for post-traumatic stress over 10 weeks. No significant differences in frequency of recovery (NDI ≤ 8%) between pragmatic and usual care groups was found at 6 or 12 months. There was no improvement in current nonrecovery rates at 6 months (63.6%, pragmatic care; 48.8%, usual care), indicating no advantage of the early multiprofessional intervention.
The panel determined low certainty in the clinical evidence, with small desirable and undesirable effects reported. Yet there were relatively small costs and resources required to implement the intervention. Electronic dissem- ination of the educational component of multimodal care may reduce health inequities. The option may be acceptable to clinicians (assuming collaborative care approaches), policymakers, and patients and is likely feasible to implement in usual care settings. Overall, the balance between the desirable and undesirable consequences is uncertain, and no recommendation is given at this time. Further studies need to be conducted in this area and should involve multimodal care including high-velocity proce- dures or manipulation.
Key Question 32: Should structured patient education vs advice be used for persistent (N3 months) WAD?
Summary of Evidence. Stewart et al. (2007)96 reported non–clinically significant between differences for pain and disability outcomes at 6 weeks. This study suggested that adding a physiotherapy-based graded exercise program to a structured advice intervention provided similar clinical benefit as structured education alone.
The panel determined low certainty of the evidence, with low desirable and undesirable anticipated effects. The main complaints were muscle pain, knee pain, and spinal pain with mild headaches.96 The small resources required for the intervention may reduce health inequities, and the option is acceptable to stakeholders and feasible to implement in most settings.
The panel determined that this key question had substantial overlap with Key Question 5 and decided to make 1 recommendation addressing both topics.
This evidence-based guideline establishes the best practice for the management of NAD and WAD resulting from or aggravated by a motor vehicle collision and updates 2 previous guidelines on similar topics.24,25 This guideline covers recent-onset (0-3 months) and persistent (N3 months) NADs and WADs grades I to III. It does not cover the management of musculoskeletal thoracic spine or chest wall pain.
The primary outcomes reported in the selected studies were neck pain intensity and disability. Although all recommendations included in this guideline are based on low risk of bias RCTs, the overall quality of evidence is generally low considering other factors considered by GRADE such as imprecision, and thus the strength of recommendations is weak at this time. Weak recommen- dations mean that clinicians need to devote more time to the process of shared decision making and ensure that the informed choice reflects patient values and preferences.56 Interventions not described in this guideline cannot be recommended for the management of patients with NAD or WAD because of a lack of evidence about their effective- ness and safety (Table 16).
A recent systematic review and meta-analysis by Wiangkham (2015)101 on the effectiveness of conservative management for acute WAD grade II included 15 RCTs, all assessed as high risk of bias (n = 1676 participants), across 9 countries. Authors concluded that conservative interven- tions (noninvasive treatment), including active mobilization exercises, manual techniques, physical agents, multimodal therapy, behavioral approaches, and education, are gener- ally effective for recent-onset WAD grade II to reduce pain in the medium and long term and to improve cervical ROM in the short term compared with standard or control intervention.101 Although findings from the Wiangkham review are generally in line with those from the systematic reviews we included in this guideline,24,25 the pooling of high risk of bias and of clinically heterogeneous trials seriously challenges the validity of this more recent review.
First, the recommendations for the management of minor injuries of the neck were recently released by the Ministry of Finance of Ontario in collaboration with the OPTIMa Collaboration 20 and published as a separate guideline. 27 They considered the risks of bias of included RCTs using the SIGN criteria45 and the guideline recommendations developed using the modified OHTAC framework,28 based on 3 decision determinants1: overall clinical benefit (evidence of effectiveness and safety) 2 ; value for money (evidence of cost-effectiveness where available); and3 consistency with expected societal and ethical values. In the current guideline, we used the GRADE approach, which, in addition to considering risk of bias of included RCTs, takes into account 4 other factors (imprecision, inconsistency, indirectness, publication bias) to rate the confidence in effect estimates (quality of evidence) for each outcome.102 As a result of imprecision of estimates in several RCTs, the overall quality of admissible studies was deemed low. GRADE considers similar decision determi- nants as the modified OHTAC to develop recommendations when subsequently making an overall rating of confidence in effect estimates across all outcomes based on those outcomes considered critical to a particular recommenda- tion.56 Accordingly, the guideline panel was asked to consider this low quality of evidence when judging the “desirable” consequences. When the benefits of important outcomes slightly outweighed undesirable effects of the intervention, a weak recommendation was made (ie, suggestions for care). This is likely to involve ensuring patients understand the implications of the choices they are making, possibly using a formal decision aid.56 However, if the judgment was “closely balanced or uncertain,” no recommendation could be made.
Second, OPTIMa 20 recommended that interventions should only be provided in accordance with published evidence for effectiveness, including parameters of dosage, duration, and frequency, and within the most appropriate phase. The emphasis during the early phase (0-3 months) should be on education, advice, reassurance, activity, and encouragement. Health care professionals should be encouraged to consider watchful waiting and clinical monitoring as evidence-based therapeutic options during the acute phase. For injured persons requiring therapy, time-limited and evidence-based interventions should be implemented on a shared decision-making basis, an approach that equally applies to patients in the persistent phase (4-6 months). Despite using slightly different methods to derive recommendations, the 2 processes generally led to similar guidance.
Third, OPTIMa20 reported that the following interven- tions are not recommended for recent-onset NAD: struc- tured patient education alone (either verbal or written); strain-counterstrain or relaxation massage; cervical collar; electroacupuncture (electrical stimulation of acupuncture points with acupuncture needles or electrotherapy applied to the skin), a topic not covered in our guideline; electric muscle stimulation; heat (clinic based). Similarly for persistent NAD, programs solely of clinic-based supervised high-dose strengthening exercises, strain-counterstrain or relaxation massage, relaxation therapy for pain or disability outcomes, transcutaneous electrical nerve stimulation (TENS), electric muscle stimulation, pulsed shortwave diathermy, heat (clinic based), electroacupuncture, and botulinum toxin injec- tions are not recommended. In contrast, based on the RCT by Zebis et al.91 the current guideline suggests offering multimodal care and/or patient education for industrial workers presenting with neck pain grades I to III. Although structured patient education used alone cannot be expected to yield large benefits for patients with neck pain, this strategy may be of benefit during the recovery of patients with persistent WAD when used as an adjunct therapy.40 For persistent neck pain (grades I-II), Gustavsson et al.80 reported that multimodal care combining manual therapy (spinal manipulation, mobilization, massage, traction) and passive modalities (heat, TENS, exercise, and/or ultrasound) reduced neck disability. It should be noted, however, that past reviews were unable to make any definitive conclusions about the effectiveness of TENS as an isolated treatment for acute pain 103 or chronic pain 104 in adults, nor about the effectiveness of heat therapy.105,106
A comparison of the recommendations with 2 previous chiropractic guidelines 24,25 reveals that a multimodal approach including manual therapy, advice, and exercise remains the overall recommended strategy of choice for the treatment of neck pain. However, treatment modalities included in recommended multimodal care differed accord- ing to the quality of the evidence available at the time. The 2010 guideline on the management of WAD developed treatment recommendations based on low-quality evidence from 8 available RCTs and 3 cohort studies.25 Overall, recommendations for recent and persistent WAD are similar (multimodal care, and supervised exercise and multidisciplinary care, respectively). The 2014 guideline on neck pain24 developed 11 treatment recommendations from 41 RCTs. The current guideline developed 13 recommenda- tions from 26 low risk of bias RCTs. In line with the 2014 guideline24 for recent-onset neck pain, the current recom- mendations suggest offering multimodal care including mobilization, advice, and exercises. The current guideline recommendations also suggest offering supervised graded strengthening and stability exercises. Similar to the 2014 guideline for persistent neck pain (grades I-II),24 the current recommendations suggest offering multimodal care consisting of manual therapy (spinal manipulation therapy or mobilization) and exercises. Details on specific exercise modalities are now provided, including suggestions for supervised and unsuper- vised exercises, strength training, and supervised group exercises such as workplace exercise programs and supervised yoga.
This guideline did not specifically review the evidence on adverse events from treatments. However, in the review by Wong et al.42 on manual therapy and passive modalities, 22 of the low risk of bias RCTs addressed the risk of harm from conservative care. Most adverse events were mild to moderate and transient (mostly increased stiffness and pain at the site of treatment, with a mean rate of about 30%). No serious neurovascular adverse events were reported. Another review of published RCTs and prospective cohort studies confirmed that around half of people treated with manual therapy can expect minor to moderate adverse events after treatment, but that the risk of major adverse events is small.107 The pooling of data from RCTs of manual therapy on the incidence of adverse events indicated that the relative risk of minor or moderate adverse events was similar for manual therapy and exercise treatments, and for sham/passive/control interventions.
A patient-centered holistic and collaborative view of the needs of the patient with pain and disability is encouraged. 108,109 Although chiropractors are not responsible for pharmacologic management, they should have sufficient knowledge about pharmacologic agents and their adverse events. One eligible RCT22 found home exercises and advice to be as effective as medication (acetaminophen, NSAIDs, muscle relaxant, and opioid analgesic) in reducing pain and disability at short term for patients with acute or subacute neck pain grades I to II. However, medication was associated with a higher risk for adverse events. Of interest, recent evidence suggests that acetaminophen is not effective for managing low back pain,110,111 and the effectiveness of long-term opioid therapy for improving chronic pain and function is uncertain.64 However, a dose-dependent risk for serious harms is associated with long-term use of opioid (increased risk for overdose, opioid abuse and dependence, fractures, myocardial infarction, and use of medications to treat sexual dysfunction).64 Risk of unintentional opioid overdose injury appears to be particularly important in the first 2 weeks after initiation of long-acting agents.112,113
Choosing a Care Provider. A range of health care providers (chiropractors, general medical practitioners, physiothera- pists, registered massage therapists, and osteopaths) deliver care for NADs and WADs.108,114 Considering the level of skills required to deliver manual therapy, including spinal manipulative therapy and other forms of therapies (eg, prescription of specific exercise) and based on individual patient preference, cervical spine manipulation as part of multimodal care should be delivered by properly trained licensed professionals. 115
This guideline specifically addresses the treatment of NAD and WAD grades I to III. Importantly, our panel supports the following 5 best practice recommendations on patients care outlined in the OPTIMa guideline27: Clinicians should1 rule out major structural or other pathologic conditions as the cause of neck pain–associated disorders before classifying as grade I, II, or III2; assess prognostic factors for delayed recovery3; educate and reassure patients about the benign and self-limited nature of the typical course of NAD grades I to III and the importance of maintaining activity and movement4; refer patients with worsening symptoms and those who develop new physical or psychological symptoms for further evaluation at any time during their care; and5 reassess the patient at every visit to determine whether additional care is necessary, the condition is worsening, or the patient has recovered. Patients reporting significant recovery should be discharged. Similar recommendations were formulated by the Neck Pain Task Force116 and in prior practitioner guides on the management of WAD and NAD by chiropractors.24,25
Benefits of Physical Activity and Self-management. Educating patients about the benefits of being physically active and participating in their care has become the standard of care internationally. Despite the benefits of therapeutic exercise for managing chronic neck pain and the strong evidence favoring regular physical activity to reduce related comorbidities, care providers fail to routinely prescribe these to patients.117-120 When prescribed, the amount of supervision and types of exercises do not follow practice guidelines and are not linked to the degree of patient impairment.118,121 On the patient side, adherence to prescribed exercise programs is often low. 122
The promotion of physical activity, including exercise, is a first-line treatment considered important in the prevention and treatment of musculoskeletal pain and its related comorbidities (eg, coronary heart disease, type 2 diabetes, and depression).123-126 For a minority of patients with chronic spine pain, clinician-delivered interventions and pharmacologic treatments are appropriate; and in fewer cases, multidisciplinary pain management or surgery may be indicated. 118
People with musculoskeletal pain will often adopt an inactive lifestyle. Unfortunately, physical inactivity is associated with important adverse health effects, including increased risks of coronary heart disease, type 2 diabetes, and breast and colon cancers, and shorter life expectancy in general.127 The World Health Organization128 provided clear guidance on physical activity for health for children, adults, and elders. In addition, recent research suggests that WAD patients with high levels of passive coping strategies have slower pain and disability recovery.129 Self-management support (SMS) strategies aimed at increasing physical activity and active coping strategies are key to effectively managing spinal pain and related comorbidities. 124,125,130-134 The CCGI developed a theory-based knowledge translation (KT) intervention targeting identified barriers to professional behavior change to increase the uptake of SMS strategies among Canadian chiropractors.135 Interviews of clinicians identified 9 theoretical domains as likely relevant (ie, factors perceived to influence the use of multimodal care to manage nonspecific neck pain).135 The intervention, comprising a webinar and a learning module on Brief Action Planning, is a highly structured SMS strategy that allows patient- centered goals136 and is being pilot-tested among Canadian chiropractors (ongoing pilot trial).137 Care providers are encouraged to perform periodic clinical revaluations and to monitor patient progression of self-management strategies while discouraging dependence on passive treatment.
Overall, the quality of the research on conservative management of NADs and WADs remains low, partly explaining that only weak recommendations could be formulated for clinical practice. Further, the reporting of RCTs remains suboptimal. 138 Past recommendations for improving the quality of the research still apply.24,25 Future research should aim to clarify the role of spinal manipulation therapy alone or as part of multimodal care for the management of recent neck pain and have adequate frequency and length of follow-up. For instance, a large number of patient visits to the emergency departments each year are for acute neck and arm pain resulting from WADs.14,139 A small RCT suggested that cervical spine manipulation is a reasonable alternative to intramuscular NSAID for immediate pain relief in these patients.63 However, the small sample size, comparison of a single session of spinal manipulation to an NSAID injection, and a 1-day follow-up was not representative of clinical practice.
Few recent adequately controlled high-quality research studies of chiropractic care for NADs have been published. In addition, studies included in the reviews did not estimate the maximum therapeutic benefits (ie, best dosage for treatment under evaluation). Well-designed clinical trials with sufficient numbers of participants, longer-term treatments, and follow-up periods are needed to increase the confidence in the recommendations and to advance our understanding of effective and cost-effective conservative care, and spinal manipulation, for the management of patients with NADs and WADs.
Dissemination and Implementation Plan. Evidence-based practice aims to improve clinical decision making and patient care.140,141 When followed, CPGs have the potential to improve health outcomes and the efficiency of the health care system.142-144 However, low adherence to CPGs has been noted across health care sectors145 and in the management of musculoskeletal conditions, including NADs and WADs.77,101,102 Such gaps contribute to wide geographic variations in the use and quality of health care services. 146
Efforts to bridge the “research-practice gap” have led to a growing interest in KT.145,147 Knowledge translation is defined as the exchange, synthesis, and ethically sound application of knowledge to improve health and provide more effective health services. 148 Knowledge translation aims to bridge the research-practice gap and improve patient outcomes by promoting the integration and exchange of research and evidence-based knowledge into clinical practice.
To prepare for guideline implementation, we considered the Guideline Implementation Planning Checklist 149 and available strategies and supporting evidence141,150 to increase guideline uptake. Although effects of KT inter- ventions tend to be modest, they are likely important at a population health level.37
To raise awareness, chiropractic professional organiza- tions are encouraged to inform their members of new CCGI guidelines and tools easily accessible on our website (www. chiroguidelines.org). The guideline implementation tools framework was used to clarify the objectives of the tools; identify end users and the context and setting where tools will be used; provide instructions for use; and describe methods to develop the tools and related evidence and to evaluate the tools.151 Implementation tools designed to increase guideline uptake include practitioner and patients’ handouts (Fig. 8, Appendix 7); algorithms (Figs. 6 and 7), webinars, videos, and learning modules (http://www.cmcc. ca/CE); point-of-care checklists; and health status reminders.152-154 The CCGI has established a network of opinion leaders across Canada (www.chiroguidelines.org). Based on successful efforts to implement a WAD guideline in Australia using opinion leaders among regulated physiotherapists, chiropractors, and osteopaths, 155 the CCGI is planning a series of implementation studies among Canadian chiropractors.137 We will also pilot within chiropractic practice-based research networks.156 Monitor- ing guideline use in chiropractic is challenging because the use of electronic health records to routinely collect clinical practice information is not common in Canada and those using electronic health records often collect different indicators. 157 Nonetheless, the frequency of downloads (posting of the open access guideline on the CCGI website) and number of registering participants and completion of educational online material (webinar, video, and learning module) will be monitored monthly as proxy measures of guideline uptake.
The methods for updating the guideline will be as follows: 1) Monitoring changes in evidence, available interventions, importance and value of outcomes, resources available or relevance of the recommendations to clinicians (limited systematic literature searches each year for 3-5 years and survey to experts in the field annually): 2) assessing the need to update (relevance of the new evidence or other changes, type and scope of the update); and 3) communi- cating the process, resources, and timeline to the Guideline Advisory Committee of the CCGI, who will submit a recommendation to the Guideline Steering Committee to make a decision to update and schedule the process.158-163
Shortcomings for this guideline include the low quantity and quality of supporting evidence found during the searches. Most of the downgrading of evidence supporting the outcomes occurred because of imprecision. In addition, our updated search of the published reports included 2 databases (Medline and Cochrane Central Register of Controlled Trials) but was limited to the English published reports, which possibly excluded some relevant studies. This, however, is an unlikely source of bias.164,165 Qualitative studies that explored the lived experience of patients were not included. Thus, this review cannot comment on how patients valued and experi- enced their exposure to manual therapies or passive physical modalities. Although the composition of the guideline panel was diverse, with experienced methodologists, expert clini- cians, and stakeholder and patient representatives, only 1 member was from another health discipline (physiotherapist). The scope of this guideline focused on selected outcomes such as pain and disability, although included studies assessed several additional outcomes.
This CPG supersedes the original (2005) and revised (2014) neck pain guideline as well as the 2010 whiplash-associated guidelines produced by the Canadian Chiropractic Association (CCA); Canadian Federation of Chiropractic Regulatory and Educational Accrediting Boards (CFCREAB).
People should receive care based on evidence-based therapeutic options. Based on patient preference and resources available, a mixed multimodal approach includ- ing manual therapy and advice about self-management and exercise (supervised/unsupervised or at home) may be an effective treatment strategy for recent-onset and persistent NAD and WAD grades I to III. Progress should be regularly monitored for evidence of benefit, in particular on the basis of pain alleviation and reduction of disability.
Funds provided by the Canadian Chiropractic Research Foundation. The views of the funding body have not influenced the content of the guideline. No conflicts of interest were reported for this study.
The evidence-based practice guidelines published by the CCGI include recommendations intended to optimize patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options.21 Guidelines are intended to inform clinical decision making, are not prescriptive in nature, and do not replace professional chiropractic care or advice, which always should be sought for any specific condition. Furthermore, guidelines may not be complete or accurate because new studies that have been published too late in the process of guideline development or after publication are not incorporated into any particular guideline before it is disseminated. CCGI and its working group members, executive committee, and stakeholders (the “CCGI Parties”) disclaim all liability for the accuracy or completeness of a guideline, and disclaim all warranties, expressed or implied. Guideline users are urged to seek out newer information that might impact the diagnostic and/or treatment recommendations contained within a guideline. The CCGI Parties further disclaim all liability for any damages whatsoever (including, without limitation, direct, indirect, incidental, punitive, or consequential damages) arising out of the use, inability to use, or the results of use of a guideline, any references used in a guideline, or the materials, information, or procedures contained in a guideline, based on any legal theory whatsoever and whether or not there was advice of the possibility of such damages.
Through a comprehensive and systematic literature review, CCGI evidence-based CPGs incorporate data from the existing peer-reviewed literature. This literature meets the prespecified inclusion criteria for the clinical research question, which CCGI considers, at the time of publication, to be the best evidence available for general clinical information purposes. This evidence is of varying quality from original studies of varying methodological rigor. CCGI recommends that performance measures for quality improvement, performance-based reimbursement, and public reporting purposes should be based on rigorously developed guideline recommendations.
We thank the following people for their contributions to this paper: Dr. John Riva, DC, observer; Heather Owens, Research Coordinator, proofreading; Cameron McAlpine (Director of Communication & Marketing, Ontario Chiro- practic Association), for assistance in producing the companion document intended for patients with NAD; members of the guideline panel who served on the Delphi consensus panel, who made this project possible by generously donating their expertise and clinical judgment.
In conclusion, whiplash-associated disorders can cause damage to the complex structures of the cervical spine, or neck, because the sheer force of an impact can extend the soft tissues beyond their natural range of motion. Many healthcare professionals can safely and effectively treat whiplash as well as other automobile accident injuries. The results of the article above demonstrate that a multimodal approach, including manual therapy, self-management advice and exercise can be an efficient treatment strategy for both recent-onset and persistent neck pain caused by whiplash-associated disorders. Information referenced from the National Center for Biotechnology Information (NCBI). The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
According to statistics, approximately 80% of people will experience symptoms of back pain at least once throughout their lifetimes. Back pain is a common complaint which can result due to a variety of injuries and/or conditions. Often times, the natural degeneration of the spine with age can cause back pain. Herniated discs occur when the soft, gel-like center of an intervertebral disc pushes through a tear in its surrounding, outer ring of cartilage, compressing and irritating the nerve roots. Disc herniations most commonly occur along the lower back, or lumbar spine, but they may also occur along the cervical spine, or neck. The impingement of the nerves found in the low back due to injury and/or an aggravated condition can lead to symptoms of sciatica.
1. Ferrari R, Russell A. Regional musculoskeletal conditions: neck pain. Best Pract Res Clin Rheumatol. 2003;17(1):57-70.
2. Hogg-Johnson S, van der Velde G, Carroll LJ, et al. The burden and determinants of neck pain in the general population: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. Spine.
3. Holm L, Carroll L, Cassidy JD, et al. The burden and
determinants of neck pain in whiplash-associated disorders after traffic collisions: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. Spine. 2008;33(4 Suppl):S52-S59.
4. Côté P, van der Velde G, Cassidy JD, et al. The burden and determinants of neck pain in workers: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. Spine. 2008;33(4 Suppl): S60-S74.
5. Vos T, Flaxman A, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859): 2163-2196.
6. Côté P, Cassidy JD, Carroll L. The treatment of neck and low back pain: who seeks care? Who goes where? Med Care. 2001;39(9):956-967.
7. Hoy DG, Protani M, De R, Buchbinder R. The epidemi- ology of neck pain. Best Pract Res Clin Rheumatol. 2010; 24(6):783-792.
8. Murray C, Abraham J, Ali M, et al. The state of us health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA. 2013;310(6):591-606.
9. Manchikanti L, Singh V, Datta S, Cohen S, Hirsch J. Physicians. ASoIP. Comprehensive review of epidemiolo- gy, scope, and impact of spinal pain. Pain Physician. 2009; 12(4):E35-E70.
10. Hincapié C, Cassidy J, Côté P, Carroll L, Guzmán J. Whiplash injury is more than neck pain: a population-based study of pain localization after traffic injury. J Occup Environ Med. 2010;52(4):434-440.
11. Blincoe L, Miller T, Zaloshnja E, Lawrence B. The Economic and Societal Impact of Motor Vehicle Crashes, 2010. (Revised) (Report No. DOT HS 812 013). Washington, DC: National Highway Traffic Safety Administration; 2015.
12. Bannister G, Amirfeyz R, Kelley S, Gargan M. Whiplash injury. J Bone Joint Surg. 2009;91-B(7):845-850.
13. Johansson M, Boyle E, Hartvigsen J, Carroll L, Cassidy J. A population-based, incidence cohort study of mid-back pain after traffic collisions: factors associated with global recovery. EuroJ Pain. 2015;19(10):186-195.
14. Styrke J, Stalnacke B, Bylund P, Sojka P. A 10-year incidence of acute whiplash injuries after road traffic crashes in a defined population in northern Sweden. PM R. 2012;4(10):739-747.
15. Ontario MoFo. Ontario Auto Insurance Anti-Fraud Task Force Interim Report. Available at: http://www.fin.gov.on. ca/en/autoinsurance/interim-report.pdf Accessed May 7, 2016.
16. Karlsborg M, Smed A, Jespersen H, et al. A prospective study of 39 patients with whiplash injury. Acta Neurol Scand. 1997;95(2):65-72.
17. Sterling M, Jull G, Vicenzino B, Kenardy J, Darnell R. Development of motor system dysfunction following whiplash injury. Pain. 2003;103(1-2):65-73.
18. Guzman J, Hurwitz EL, Carroll LJ, et al. A new conceptual model of neck pain: linking onset, course, and care: the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. Spine. 2008;33(4 Suppl): S14-S23.
19. Leaver A, Maher C, McAuley J, Jull G, Refshauge K. Characteristics of a new episode of neck pain. Man Ther. 2013;18(3):254-257.
20. Côté P, Shearer H, Ameis A, et al. Enabling recovery from common traffic injuries: a focus on the injured person. UOIT-CMCC Centre for the Study of Disability Prevention and Rehabilitation; 2015.
21. Clar C, Tsertsvadze A, Court R, Hundt G, Clarke A, Sutcliffe P. Clinical effectiveness of manual therapy for the management of musculoskeletal and non-musculoskeletal conditions: systematic review and update of UK evidence report. Chiropract Man Ther. 2014;22(1):12.
22. Bronfort G, Evans R, Anderson A, Svendsen K, Bracha Y, Grimm R. Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain. Ann Intern Med. 2012;156(1 Part 1):1-10.
23. Hurwitz EL, Carragee EJ, van der Velde G, et al. Treatment of neck pain: noninvasive interventions. Results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and its Associated Disorders. Spine. 2008;33(4S):S123-S152.
24. Bryans R, Decina P, Descarreaux M, et al. Evidence-based guidelines for the chiropractic treatment of adults with neck pain. J Manip Physiol Therap. 2014;37(1):42-63.
25. Shaw L, Descarreaux M, Bryans R, et al. A systematic review of chiropractic management of adults with whiplash- associated disorders: recommendations for advancing evidence-based practice and research. Work. 2010;35(3): 369-394.
26. Graham G, Mancher M, Miller Wolman D, Greenfield S, Steinberg E, editors. Clinical Practice Guidelines We Can Trust. Institute of Medicine, Shaping the Future for Health.
Washington, DC: National Academies Press; 2011.
27. Côté P, Wong JJ, Sutton D, et al. Management of neck pain and associated disorders: a clinical practice guideline from the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Euro Spine J. 2016;25(7): 2000-2022.
28. Johnson AP, Sikich NJ, Evans G, et al. Health technology assessment: a comprehensive framework for evidence- based recommendations in ontario. Int J Technol Assess Health Care. 2009;25(2):141-150.
29. Shukla V, Bai A, Milne S, Wells G. Systematic review of the evidence grading system for grading level of evidence. German J Evid Qual Health Care. 2008; 102:43.
30. Mustafa RA, Santesso N, Brozek J, et al. The GRADE approach is reproducible in assessing the quality of evidence of quantitative evidence syntheses. J Clin Epidemiol. 2013;66(7):736-742.e5.
31. Woolf S, Schunemann H, Eccles M, Grimshaw J, Shekelle P. Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations. lImplementation Sci. 2012;7(1):61.
32. Tricco A, Tetzlaff J, Moher D. The art and science of knowledge synthesis. J Clin Epidemiol. 2011;64(1):11-20.
33. Guyatt G, Eikelboom JW, Akl EA, et al. A guide to GRADE
guidelines for the readers of JTH. J Thromb Haemost. 2013;
34. Adaptation. The ADAPTE Manual and Resource
Toolkit V2. G-I-N Adaptation Working Group. Available at: http://www.g-i-n.net/working-groups/adaptation Accessed May 16, 2016.
35. Brouwers M, Kho M, Browman G, et al. AGREE II: advancing guideline development, reporting and evalua- tion in health care. J Clin Epidemiol. 2010;63(12): 1308-1311.
36. Flottorp S, Oxman AD, Cooper JG, Hjortdahl P, Sandberg S, Vorland LH. Retningslinjer for diagnostikk og behand- ling av sar hals. Tidsskr Nor Laegeforen. 2000;120: 1754-1760.
37. Grimshaw J, Eccles M, Lavis J, Hill S, Squires J. Knowledge translation of research findings. Implementation Sci. 2012;7(1):50.
38. Southerst D, Nordin M, Côté P, et al. Is exercise effective for the management of neck pain and associated disorders or whiplash-associated disorders? A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Spine J. 2014;S1529-1530(14): 00210-1.
39. Sutton D, Cote P, Wong J, et al. Is multimodal care effective for the management of patients with whiplash-associated disorders or neck pain and associated disorders? A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Spine J. 2014 [S1529-9430(14):00650-0].
40. Yu H, Côté P, Southerst D, Wong J, et al. Does structured patient education improve the recovery and clinical outcomes of patients with neck pain? A systematic review from the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Spine J. 2014;pii: S1529- 9430(14).
41. Varatharajan S, Côté P, Shearer H, et al. Are work disability prevention interventions effective for the management of neck pain or upper extremity disorders? A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. J Occup Rehabil. 2014;24(4): 692-708.
42. Wong JJ, Shearer HM, Mior S, et al. Are manual therapies, passive physical modalities, or acupuncture effective for the management of patients with whiplash-associated disorders or neck pain and associated disorders? An update of the Bone and Joint Decade Task Force on Neck Pain and Its Associated Disorders by the Optima Collaboration. Spine J. 2015;20(8 Suppl).
43. Shea B, Grimshaw J, Wells G, Boers M, Andersson N, Hamel C. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10.
44. Norman G, Streiner D. Biostatistics: The Bare Essentials. 3rd ed. Hamilton, ON: BC Decker; 2008.
45. Ricci S, Celani M, Righetti E. Development of clinical guidelines: methodological and practical issues. Neurol Sci. 2006;27(Suppl 3):S228-S230.
46. van der Velde G, van Tulder M, Côté P, et al. The sensitivity of review results to methods used to appraise and incorporate trial quality into data synthesis. Spine. 2007; 32(7):796-806.
47. Slavin R. Best evidence synthesis: an intelligent alternative to meta-analysis. J Clin Epidemiol. 1995;48(1):9-18.
48. Network GI, GRADE Working Group. Resources. Available at: http://www.g-i-n.net/working-groups/updating-guidelines/re- sources. Accessed May 5, 2016.
49. Guyatt G, Oxman A, Vist G, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924-926.
50. Guyatt G, Oxman A, Akl E, Kunz R, Vist G, Brozek J, et al. GRADE guidelines 1. Introduction: GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):38-94.
51. Treweek S, Oxman A, Alderson P, et al. Developing and evaluating communication strategies to support informed decisions and practice based on evidence (DECIDE): protocol and preliminary results. Implementation Sci. 2013; 8(1):6.
52. McCarthy M, Grevitt M, Silcocks P, Hobbs G. The reliability of the Vernon and Mior neck disability index, and its validity compared with the short form-36 health survey questionnaire. Eur Spine J. 2007;16(12):2111-2117.
53. Stauffer M, Taylor S, Watson D, Peloso P, Morrison A. Definition of nonresponse to analgesic treatment of arthritic pain: an analytical literature review of the smallest detectable difference, the minimal detectable change, and the minimal clinically important difference on the pain visual analog scale. Int J Inflam. 2011;2011:231926.
54. Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: visual analog scale for pain (VAS Pain), numeric rating scale for pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP. Arthritis Care Res. 2011;63(S11):S240-S252.
55. Blozik E, Himmel W, Kochen MM, Herrmann-Lingen C, Scherer M. Sensitivity to change of the Neck Pain and Disability Scale. Euro Spine J. 2011;20(6):882-889.
56. Andrews J, Guyatt G, Oxman AD, et al. GRADE guidelines: 14. Going from evidence to recommendations: the signifi- cance and presentation of recommendations. J Clin Epidemiol. 2013;66(7):719-725.
57. Andrews JC, Schünemann HJ, Oxman AD, et al. GRADE guidelines: Going from evidence to recommendation— determinants of a recommendation’s direction and strength. J Clinl Epidemiol. 2013;66(7):726-735.
58. Black N, Murphy M, Lamping D, McKee M, Sanderson C, Askham J. Consensus development methods: a review of best practice in creating clinical guidelines. J Health Serv Res Policy. 1999;4(4):236-248.
59. Seo H-J, Kim KU. Quality assessment of systematic reviews or meta-analyses of nursing interventions conducted by Korean reviewers. BMC Med Res Methodol. 2012;12:129.
60. Leaver A, Maher C, Herbert R, et al. A randomized controlled trial comparing manipulation with mobilization for recent onset neck pain. Arch Phys Med Rehabil. 2010;91(9):1313-1318.
61. Dunning J, Cleland J, Waldrop M, et al. Upper cervical and upper thoracic thrust manipulation versus nonthrust mobiliza- tion in patients with mechanical neck pain: a multicenter randomized clinical trial. J Orthop Sports Phys Ther. 2012; 42(1):5-18.
62. Nagrale A, Glynn P, Joshi A, Ramteke G. The efficacy of an integrated neuromuscular inhibition technique on upper trapezius trigger points in subjects with non-specific neck pain: a randomized controlled trial. J Man Manip Ther. 2010; 18(1):37-43.
63. McReynolds T, Sheridan B. Intramuscular ketorolac versus osteopathic manipulative treatment in the management of acute neck pain in the emergency department: a randomized clinical trial. JAOA. 2005;105(2):57-68.
64. Chou R, Turner JA, Devine EB, et al. The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop Effectiveness and Risks of Long-Term Opioid Therapy for Chronic Pain. Ann Inter Med. 2015;162(4):276-286.
65. Kuijper B, Tans J, Beelen A, Nollet F, de Visser M. Cervical collar or physiotherapy versus wait and see policy for recent onset cervical radiculopathy: randomised trial. BMJ. 2009;339:b3883.
66. Cassidy J. Mobilisation or immobilisation for cervical radiculo- pathy? BMJ. 2009;339(b):3952.
67. Konstantinovic L, Cutovic M, Milovanovic A, et al. Low-level laser therapy for acute neck pain with radiculopathy: a double- blind placebo-controlled randomized study. Pain Med. 2010; 11(8):1169-1178.
68. van den Heuvel S, de Looze M, Hildebrandt V, Thé K. Effects of software programs stimulating regular breaks and exercises on work-related neck and upper-limb disorders. Scand J Work Environ Health. 2003;29(2):106-116.
69. Lamb S, Gates S, Williams M, et al. Emergency department treatments and physiotherapy for acute whiplash: a pragmatic, two-step, randomised controlled trial. Lancet. 2013;381(9866): 546-556.
70. Ferrari R, Rowe BH, Majumdar SR, et al. Simple educational intervention to improve the recovery from acute whiplash: results of a randomized, controlled trial. Acad Emerg Med. 2005;12(8): 699-706.
71. von Trott P, Wiedemann A, Lüdtke R, Reißhauer A, Willich S, Witt C. Qigong and exercise therapy for elderly patients with chronic neck pain (QIBANE): a randomized controlled study. J Pain. 2009;10(5):501-508.
72. Rendant D, Pach D, Ludtke R, et al. Qigong versus exercise versus no therapy for patients with chronic neck pain: a randomized controlled trial. Spine. 2011;36(6):419-427.
73. Michalsen A, Traitteur H, Lüdtke R, et al. Yoga for chronic neck pain: a pilot randomized controlled clinical trial. J Pain. 2012; 13(11):1122-1130.
74. Jeitler M, Brunnhuber S, Meier L, et al. Effectiveness of jyoti meditation for patients with chronic neck pain and psychological distress-a randomized controlled clinical trial. J Pain. 2015;16(1): 77-86.
75. Hakkinen A, Kautiainen H, Hannonen P, Ylinen J. Strength training and stretching versus stretching only in the treatment of patients with chronic neck pain: a randomized one-year follow-up
study. Clin Rehabil. 2008;22(7):593-600.
76. Salo P, Ylonen-Kayra N, Hakkinen A, Kautiainen H, Malkia E,
Ylinen J. Effects of long-term home-based exercise on health- related quality of life in patients with chronic neck pain: a randomized study with a 1-year follow-up. Disabil Rehabil. 2012; 34(23):1971-1977.
77. Evans R, Bronfort G, Schulz G, et al. Supervised exercise with and without spinal manipulation performs similarly and better than home exercise for chronic neck pain: a randomized controlled trial. Spine. 2012;37(11):903-914.
78. Maiers M, Bronfort G, Evans R, et al. Spinal manipulative therapy and exercise for seniors with chronic neck pain. Spine J. 2014;14(9):1879-1889.
79. Griffiths C, Dziedzic K, Waterfield J, Sim J. Effectiveness of specific neck stabilization exercises or a general neck exercise program for chronic neck disorders: a randomized controlled trial. J Rheumatol. 2009;36(2):390-397.
80. Gustavsson C, Denison E, von Koch L. Self-management of persistent neck pain: a randomized controlled trial of a multi- component group intervention in primary health care. Eur J Pain. 2010;14(6):630.e1-11.
81. Gustavsson C, Denison E, von Koch L. Self-management of persistent neck pain: two-year follow-up of a randomized controlled trial of a multicomponent group intervention in primary health care. Spine. 2011;36(25):2105-2115.
82. Sherman K, Cherkin D, Hawkes R, Miglioretti D, Deyo R. Randomized trial of therapeutic massage for chronic neck pain. Clin J Pain. 2009;25(3):233-238.
83. Lin J, Shen T, Chung R, Chiu T. The effectiveness of Long’s manipulation on patients with chronic mechanical neck pain: a randomized controlled trial. Manual Ther. 2013;18(4):308-315.
84. Lauche R, Materdey S, Cramer H, et al. Effectiveness of home- based cupping massage compared to progressive muscle relaxation in patients with chronic neck pain—a randomized controlled trial. PLoS One. 2013;8(6):e65378.
85. Sherman K, Cook A, Wellman R, et al. Five-week outcomes from a dosing trial of therapeutic massage for chronic neck pain. Ann Fam Med. 2014;12(2):112-120.
86. Walker MJ, Boyles RE, Young BA, et al. The effectiveness of manual physical therapy and exercise for mechanical neck pain: a randomized clinical trial. Spine (Phila Pa 1976). 2008;33(22): 2371-2378.
87. Boyles R, Walker M, Young B, Strunce J, Wainner R. The addition of cervical thrust manipulations to a manual physical therapy approach in patients treated for mechanical neck pain: a secondary analysis. J Orthop Sports Phys Ther. 2010;40(3): 133-140.
88. Hoving JL, de Vet HC, Koes BW, et al. Manual therapy, physical therapy, or continued care by the general practitioner for patients with neck pain: long-term results from a pragmatic randomized clinical trial. Clin J Pain. 2006;22(4):370-377.
89. Hoving JL, Koes BW, de Vet HCW, et al. Manual Therapy, physical therapy, or continued care by a general practitioner for patients with neck pain: a randomized, controlled trial. Ann Intern Med. 2002;136(10):713-722.
90. Monticone M, Baiardi P, Vanti C, et al. Chronic neck pain and treatment of cognitive and behavioural factors: results of a randomised controlled clinical trial. Euro Spine J. 2012;21(8): 1558-1566.
91. Zebis M, Andersen L, Pedersen M, et al. Implementation of neck/shoulder exercises for pain relief among industrial workers: a randomized controlled trial. BMC Musculoskelet Disord. 2011;12:205.
92. Zebis MK, Andersen CH, Sundstrup E, Pedersen MT, Sjøgaard G, Andersen LL. Time-wise change in neck pain in response to rehabilitation with specific resistance training: implications for
exercise prescription. PLoS One. 2014;9(4):e93867.
93. Andersen C, Andersen L, Gram B, et al. Influence of frequency and duration of strength training for effective management of neck and shoulder pain: a randomised controlled trial. Br J
Sports Med. 2012;46(14):1004-1010.
94. Andersen L, Jorgensen M, Blangsted A, Pedersen M, Hansen E,
Sjogaard GA. randomized controlled intervention trial to relieve and prevent neck/shoulder pain. Med Sci Sports Exerc. 2008; 40(6):983-990.
95. Sjogren T, Nissinen K, Jarvenpaa S, Ojanen M, Vanharanta H, Malkia E. Effects of a workplace physical exercise intervention on the intensity of headache and neck and shoulder symptoms and upper extremity muscular strength of office workers: a cluster randomized controlled cross-over trial. Pain. 2005;116(1-2):119-128.
96. Stewart M, Maher C, Refshauge K, Herbert R, Bogduk N, Nicholas M. Randomized controlled trial of exercise for chronic whiplash-associated disorders. Pain. 2007;128(1-2):59-68.
97. Michaleff Z, Maher C. Lin C-WC, et al. Comprehensive physiotherapy exercise programme or advice for chronic whiplash (PROMISE): a pragmatic randomised controlled trial. Lancet. 2014;384(9938):133-141.
98. Gram B, Andersen C, Zebis MK, et al. Effect of training supervision on effectiveness of strength training for reducing neck/shoulder pain and headache in office workers: cluster randomized controlled trial. BioMed Ress Int. 2014;2014:9.
99. Jull G, Sterling M, Kenardy J, Beller E. Does the presence of sensory hypersensitivity influence outcomes of physical reha- bilitation for chronic whiplash? A preliminary RCT. Pain. 2007; 129(1-2):28-34.
100. Jull G, Kenardy J, Hendrikz J, Cohen M, Sterling M. Management of acute whiplash: a randomized controlled trial of multidisciplin- ary stratified treatments. Pain. 2013;154(9):1798-1806.
101. Wiangkham T, Duda J, Haque S, Madi M, Rushton A. The effectiveness of conservative management for acute whiplash associated disorder (WAD) II: a systematic review and meta- analysis of randomised controlled trials. PLoS One. 2015;10(7): e0133415.
102. Guyatt G, Oxman AD, Sultan S, et al. GRADE guidelines: 11. Making an overall rating of confidence in effect estimates for a single outcome and for all outcomes. J Clin Epidemiol. 2013; 66(2):151-157.
103. Walsh D, Howe T, Johnson M, Sluka K. Transcutaneous electrical nerve stimulation for acute pain. Cochrane Database Syst Rev. 2009(2)CD006142.
104. Nnoaham K, Kumbang J. Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database Syst Rev. 2008(3)CD003222.
105. French S, Cameron M, Walker B, Reggars J, Esterman A. Superficial heat or cold for low back pain. Cochrane Database Syst Rev. 2006(1)CD004750.
106. Malanga GA, Yan N, Stark J. Mechanisms and efficacy of heat and cold therapies for musculoskeletal injury. Postgrad Med. 2015;127(1):57-65.
107. Carnes D, Mullinger B, Underwood M. Defining adverse events in manual therapies: a modified Delphi consensus study. lManual Ther. 2010;15(1):2-6.
108. Haldeman S, Carroll LJ, Cassidy JD. The empowerment of people with neck pain: introduction: the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. Spine. 2008;33(4 Suppl):S8-S13.
109. Maiers M, Vihstadt C, Hanson L, Evans R. Perceived value of spinal manipulative therapy and exercise among seniors with chronic neck pain: a mixed methods study. J Rehabil Med. 2014;46(10):1022-1028.
110. Chou R, Deyo R, Friedly J, et al. Noninvasive treatments for low back pain. Comparative Effectiveness Review No. 169. (Prepared by the Pacific Northwest Evidence-based Practice Center under Contract No. 290-2012-00014-I.). AHRQ Publication No. 16-EHC004-EF. Rockville, MD. Available at: www.effectivehealthcare.ahrq.gov/reports/final.cfm. Accessed May 15, 2016.
111. Machado G, Maher C, Ferreira P, et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ. 2015;350:h1225.
112. Miller M, Barber CW, Leatherman S, et al. Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy. JAMA Intern Med. 2015; 175(4):608-615.
113. Volkow N, McLellan A. Opioid abuse in chronic pain— misconceptions and mitigation strategies. N Engl J Med. 2016; 374(13):1253-1263.
114. Foster N, Hartvigsen J, Croft P. Taking responsibility for the early assessment and treatment of patients with musculoskeletal pain: a review and critical analysis. Arthritis Res Ther. 2012;14(1):205.
115. World Health Organization. WHO Guidelines on Basic Training and Safety in Chiropractic. Geneva, Switzerland: World Health Organization; 2005.
116. Guzman J, Haldeman S, Carroll L, et al. Clinical practice implications of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders: from concepts and findings to recommendations. Spine. 2008;33(4 Suppl):S199-S213.
117. Dietl M, Korczak D. Over-, under- and misuse of pain treatment in Germany. GMS Health Technol Assess. 2011; 7:Doc03. http://dx.doi.org/10.3205/hta000094.
118. Freburger J, Carey T, Holmes G, Wallace A, Castel L, Darter J. Exercise prescription for chronic back or neck pain: who prescribes it? Who gets it? What is prescribed? lArthritis Care Res. 2009;61:192-200.
119. Goode A, Freburger J, Carey T. Prevalence, practice patterns, and evidence for chronic neck pain. Arthritis Care Res. 2010;62(11):1594-1601.
120. Kamaleri Y, Natvig B, Ihlebaek CM, Bruusgaard D. Localized or widespread musculoskeletal pain: does it matter? Pain. 2008;138(1):41-46.
121. MacDermid J, Miller J, Gross A. Knowledge translation tools are emerging to move neck pain research into practice. lOpen Orthop J. 2013;20(7):582-593.
122. Medina-Mirapeix F, Escolar-Reina P, Gascon-Canovas J, Montilla-Herrador J, Jimeno-Serrano F, Collins S. Predictive factors of adherence to frequency and duration components in home exercise programs for neck and low back pain: an observational study. BMC Musculoskelet Disord. 2009;10(1):155.
123. Kay T, Gross A, Goldsmith C, et al. Exercises for mechanical neck disorders. Cochrane Database Syst Rev. 2012;8:CD004250.
124. Bertozzi L, Gardenghi I, Turoni F, et al. Effect of
therapeutic exercise on pain and disability in the manage- ment of chronic nonspecific neck pain: systematic review and meta-analysis of randomized trials. Phys Ther. 2013; 93(8):1026-1036.
125. Hartvigsen J, Natvig B, Ferreira M. Is it all about a pain in the back? Best Pract Res Clin Rheumatol. 2013;27(5):613-623.
126. Ambrose K, Golightly Y. Physical exercise as non-pharmaco- logical treatment of chronic pain: why and when. Best Pract Res Clin Rheumatol. 2015;29(1):120-130.
127. Lee I, Shiroma E, Lobelo F, Puska P, Blair S, Katzmarzyk P. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012;380(9838):219-229.
128. World Health Organization. Global Recommendations on Physical Activity for Health. Geneva, Switzerland: World Health Organization; 2010.
129. Carroll LJ, Ferrari R, Cassidy JD, Cote P. Coping and recovery in whiplash-associated disorders: early use of passive coping strategies is associated with slower recovery of neck pain and pain-related disability. Clin J Pain. 2014;30(1):1-8.
130. Gore M, Sadosky A, Stacey B, Tai K, Leslie D. The burden of chronic low back pain: clinical comorbidities, treatment patterns, and health care costs in usual care settings. Spine. 2012;37(11):E668-E677.
131. Bodenheimer T, MacGregor K, Charifi C. Helping patients manage their chronic conditions. Oakland, CA: California HealthCare Foundation; 2005.
132. Ritzwoller D, Crounse L, Shetterly S, Rublee D. The association of comorbidities, utilization and costs for patients identified with low back pain. BMC Musculoskelet Disord. 2006;7(1):72.
133. Sallis R, Franklin B, Joy L, Ross R, Sabgir D, Stone J. Strategies for promoting physical activity in clinical practice. Prog Cardiovasc Dis. 2015;57(4):375-386.
134. Von Korff M, Crane P, Lane M, et al. Chronic spinal pain and physical-mental comorbidity in the United States: results from the national comorbidity survey replication. Pain. 2005;113(3): 331-339.
135. Bussières A, Al Zoubi F, Quon J, et al. Fast tracking the design of theory-based KT interventions through a consensus process. Implementation Sci. 2015;10(1):18.
136. Gutnick D, Reims K, Davis C, Gainforth H, Jay M, Cole S. Brief action planning to facilitate behavior change and support patient self-management. J Clin Outcomes Manag. 2014;21: 17-29.
137. Dhopte P, Ahmed S, Mayo N, French S, Quon JA, Bussières A. Testing the feasibility of a knowledge translation intervention designed to improve chiropractic care for adults with neck pain disorders: study protocol for a pilot cluster-randomized controlled trial. Pilot and Feasibility Studies. 2016;2(1):1-11.
138. Turner L, Shamseer L, Altman D, et al. Consolidated standards of reporting trials (CONSORT) and the complete- ness of reporting of randomised controlled trials (RCTs) published in medical journals. Cochrane Database Syst Rev. 2012;11:MR000030.
139. Quinlan K, Annest J, Myers B, Ryan G, Hill H. Neck strains and sprains among motor vehicle occupants—United States, 2000. Accid Anal Prev. 2004;36(1):21-27.
140. Titler M. The evidence for evidence-based practice imple- mentation. Patient Safety and Quality: An Evidence-Based Handbook for Nurses, vol. 1. Rockville, MD: AHRQ; 2008. p. 113-161.
141. The Canadian Agency for Drugs and Technologies in Health. Rx for Change database. Available at: https://www.cadth.ca/rx-change. Accessed May 6, 2016.
142. Grimshaw J, Thomas R, MacLennan G, Fraser C, Ramsay C, Vale L. Effectiveness and efficiency of guideline dissemina- tion and implementation strategies. Health Technol Assess. 2004;8(6):1-72.
143. Bishop PB, Quon JA, Fisher CG, Dvorak MFS. The Chiropractic Hospital-based Interventions Research Outcomes (CHIRO) Study: a randomized controlled trial on the effectiveness of clinical practice guidelines in the medical and chiropractic management of patients with acute mechanical low back pain. Spine J. 2010;10(12):1055-1064.
144. Grimshaw J, Schunemann H, Burgers J, Cruz A, Heffner J, Metersky M. Disseminating and implementing guidelines. Article 13 in integrating and coordinating efforts in COPD guideline development. Proc Am Thorac Soc. 2012;9(5): 298-303.
145. Pronovost P. Enhancing physicians’ use of clinical guide- lines. JAMA. 2013;310(23):2501-2502.
146. Schuster, MA, Elizabeth A, McGlynn R, Brook H. How good is the quality of health care in the United States? Milbank. 2005;83(4):843-895.
147. Greenhalgh T, Howick J, Maskrey N. Evidence based medicine: a movement in crisis? BMJ. 2014;348:g3725. 148. Canadian Institutes of Health Research. Knowledge translation—
definition. 2008 Available at: http://www.cihr-irsc.gc.ca/e/29529.html.
Accessed May 6, 2016.
149. Gagliardi A, Marshall C, Huckson S, James R, Moore V.
Developing a checklist for guideline implementation planning: review and synthesis of guideline development and implemen- tation advice. Implementation Sci. 2015;10(1):19.
150. Cochrane-Effective Practice and Organisation of Care (EPOC). Available at: http://epoc.cochrane.org/our-reviews. Accessed May 6, 2016.
151. Gagliardi A, Brouwers M, Bhattacharyya O. A framework of the desirable features of guideline implementation tools (GItools): Delphi survey and assessment of GItools. Implementation Sci. 2014;9(1):98.
152. Okelo S, Butz A, Sharma R, et al. Interventions to modify health care provider adherence to asthma guidelines: a systematic review. Pediatrics. 2013;132(3):517-534.
153. Murthy L, Shepperd S, Clarke M, et al. Interventions to improve the use of systematic reviews in decision-making by health system managers, policy makers and clinicians. Cochrane Database Syst Rev. 2012;9CD009401.
154. Garg A, Adhikari N, McDonald H, et al. Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. JAMA. 2005; 293(10):1223-1238.
155. Rebbeck T, Macedo L, Maher C. Compliance with clinical guidelines for whiplash improved with a targeted implemen- tation strategy: a prospective cohort study. BMC Health Serv Res. 2013;13(1):213.
156. Bussières A, Côté P, French S, et al. Creating a chiropractic practice-based research network (PBRN): enhancing the management of musculoskeletal care. J Can Chiropr Assoc. 2014;58(1):8-15.
157. Canadian Chiropractic Research Database (CCRD). National Report. The Canadian Chiropractic Association: A Compre- hensive Inventory of Practical Information About Canada’s Licensed Chiropractors; 2011.
158. Becker M, Neugebauer E, Eikermann M. Partial updating of clinical practice guidelines often makes more sense than full updating: a systematic review on methods and the development of an updating procedure. J Clin Epidemiol. 2014;67(1):33-45.
159. Alonso-Coello P, Martínez García L, Carrasco JM, Solà I, Qureshi S, Burgers JS. The updating of clinical practice guidelines: insights from an international survey. Implementation Sci. 2011;6(1):1-8.
160. Martínez García L, Arévalo-Rodríguez I, Solà I, Haynes R, Vandvik P, Alonso-Coello P. Strategies for monitoring and updating clinical practice guidelines: a systematic review. Implementation Sci. 2012;7(1):1-10.
161. Moher D, Tsertsvadze A, Tricco A, et al. A systematic review identified few methods and strategies describing when and how to update systematic reviews. J Clin Epidemiol. 2007;60(11):1095. e1-11.
162. Shekelle P, Eccles M, Grimshaw J, Woolf S. When should clinical guidelines be updated? BMJ. 2001;323(7305):155-157.
163. Vernooij R, Sanabria A, Sola I, Alonso-Coello P, Martinez Garcia L. Guidance for updating clinical practice guidelines: a systematic review of methodological handbooks. Implement Sci. 2014;9:3.
164. Moher D, Pham B, Lawson M, Klassen T. The inclusion of reports of randomised trials published in languages other than English in systematic reviews. Health Technol Assess. 2003; 7(41):1-90.
165. Morrison A, Polisena J, Husereau D, et al. The effect of English-
language restriction on systematic review-based meta-analyses: a
systematic review of empirical studies. Int J Technol Assess
Health Care. 2012;28(20120426):138-144.
166. Harbour R, Miller JA. new system for grading recommen- dations in evidence based guidelines. BMJ. 2001;323(7308): 334-336.
167. Cleland J, Mintken P, Carpenter K, et al. Examination of a clinical prediction rule to identify patients with neck pain likely to benefit from thoracic spine thrust manipulation and a general cervical range of motion exercise: multi-center randomized clinical trial. Phys Ther. 2010;90(9):1239-1250.
168. Escortell-Mayor E, Riesgo-Fuertes R, Garrido-Elustondo S, et al. Primary care randomized clinical trial: Manual therapy effectiveness in comparison with TENS in patients with neck pain. Man Ther. 2011;16(1):66-73.
169. Lamb S, Williams M, Williamson E, et al. Managing Injuries of the Neck Trial (MINT): a randomised controlled trial of treatments for whiplash injuries. Health Technol Assess. 2012; 16(49:iii-iv):1-141.
170. Pool J, Ostelo R, Knol D, Vlaeyen J, Bouter L, de Vet HI. a behavioral graded activity program more effective than manual therapy in patients with subacute neck pain?: results of a randomized clinical trial. Spine. 2010;35(10): 1017-1024.
171. Skillgate E, Bohman T, Holm L, Vingård E, Alfredsson L. The long-term effects of naprapathic manual therapy on back and neck pain. Results from a pragmatic randomized controlled trial. BMC Musculoskelet Disord. 2010;11(1): 1-11.
172. Kongsted A, Qerama E, Kasch H, et al. Education of patients after whiplash injury: is oral advice any better than a pamphlet? Spine. 2008;33(22):E843-E848.
173. Andersen L, Saervoll C, Mortensen O, Poulsen O, Hannerz H, Zebis M. Effectiveness of small daily amounts of progressive resistance training for frequent neck/shoulder pain: Rando- mised controlled trial. Pain. 2011;152(2):440-446.
174. Cheng A, Hung L. Randomized controlled trial of workplace- based rehabilitation for work-related rotator cuff disorder. lJ Occup Rehab. 2007;17(3):487-503.
175. Feuerstein M, Nicholas R, Huang G, Dimberg L, Ali D, Rogers H. Job stress management and ergonomic interven- tion for work-related upper extremity symptoms. Appl Ergon. 2004;35(6):565-574.
176. van Eijsden-Besseling M, Bart Staal J, van Attekum A, de Bie RA, van den Heuvel W. No difference between postural exercises and strength and fitness exercises for early, non- specific, work-related upper limb disorders in visual display unit workers: a randomised trial. Aust J Physiother. 2008; 54(2):95-101.
177. Cameron I, Wang E, Sindhusake DA. randomized trial comparing acupuncture and simulated acupuncture for subacute and chronic whiplash. Spine. 2011;36(26):E1659-E1665.
178. Cleland JA, Glynn PE, Whitman JM, et al. Short-term response of thoracic spine thrust versus non-thrust manipulation in patients with mechanical neck pain: preliminary analysis of a randomized clinical trial. J Manual Manipulat Ther. 2007;14: 172
179. Dundar U, Evcik D, Samli F, Pusak H, Kavuncu V. The effect of gallium arsenide aluminum laser therapy in the management of cervical myofascial pain syndrome: a double blind, placebo- controlled study. Clin Rheumatol. 2007;26(6):930-934.
180. Fu W, Zhu X, Yu P, Zhang J. Analysis on the effect of acupuncture in treating 5 cervical spondylosis with different syndrome types. Chin J Integr Med. 2009;15(6):426-430.
181. Kanlayanaphotporn R, Chiradejnant A, Vachalathiti R. The immediate effects of mobilization technique on pain and range of motion in patients presenting with unilateral neck pain: a randomized controlled trial. Arch Phys Med Rehabil. 2009; 90(2):187-192.
182. Kanlayanaphotporn R, Chiradejnant A, Vachalathiti R. Immediate effects of the central posteroanterior mobiliza- tion technique on pain and range of motion in patients with mechanical neck pain. Dis Rehab. 2010;32(8): 622-628.
183. Klein R, Bareis A, Schneider A, Linde K. Strain-counter- strain to treat restrictions of the mobility of the cervical spine in patients with neck pain: a sham-controlled randomized trial. Complement Ther Med. 2013;21(1):1-7.
184. Liang Z, Zhu X, Yang X, Fu W, Lu A. Assessment of a traditional acupuncture therapy for chronic neck pain: a pilot randomised controlled study. Complementary Ther Med. 2011; 19(Suppl 1):S26-S32.
185. Masaracchio M, Cleland JA, Hellman M, Hagins M. Short-term combined effects of thoracic spine thrust manipulation and cervical spine nonthrust manipulation in individuals with mechanical neck pain: a randomized clinical trial. J Orthop Sports Phys. 2013;43(3):118-127.
186. Saavedra-Hernandez M, Castro-Sanchez A, Arroyo-Morales M, et al. Short term effects of kinesio taping versus cervical thrust manipulation in patients with mechanical neck pain: a randomized clinical trial. J Orthop Sports Phys Ther. 2012;42: 724-730.
187. Sillevis R, Hellman M, Beekhuizen K. Immediate effects of a thoracic spine thrust manipulation on the autonomic nervous system: a randomized clinical trial. J Manual Manipulat Ther. 2010;18:181-190.
188. White P, Lewith G, Prescott P, Conway J. Acupuncture versus placebo for the treatment of chronic mechanical neck pain: a randomized, controlled trial. Ann Inter Med. 2004;141(12): 911-919.
189. Young I, Cleland J, Aguilera A, et al. Manual therapy, exercise, and traction for patients with cervical radiculopathy: a randomized clinical trial. Phys Ther. 2009;89:632-642.
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